82772-22-3Relevant academic research and scientific papers
6-AMINO-QUINOLINE-3-CARBONITRILS AS COT MODULATORS
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Page/Page column 106; 107, (2017/01/26)
The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
Meta Functionalization of Anilines and Phenol
Fukui, Mineo,Ikeda, Toshiya,Oishi, Takeshi
, p. 466 - 475 (2007/10/02)
Base-promoted proton abstraction from ?-(N-tert-butyldimethylsilyl-N-methylaniline)chromium tricarbonyl (3) took place predominantly at the meta position and variously meta-substituted N-methylacetanilides 4 were obtained after reactions with electrophiles followed by oxidative decomplexation and N-acetylation.Application of the present method to variously N,N-disubstituted anilines 5 and phenols 7 was then examined and the corresponding meta substituted anilines 6 and phenol 9 were obtained.Keywords - metalation of aromatic ring; chromium tricarbonyl complex; tert-butyl dimethylsilyl protecting group; meta-substituted anilines; meta-substituted phenol; electrophilic substitution
META FUNCTIONALIZATION OF ANILINES AND PHENOL
Fukui, Mineo,Ikeda, Toshiya,Oishi, Takeshi
, p. 1605 - 1608 (2007/10/02)
Regioselective introduction of various functional groups on the meta-position of anilines and phenol was achieved by proton abstraction from chromium tricarbonyl complexes 3,5,7 with n-BuLi, followed by the addition of electrophiles and decomplexation.
