16375-94-3

Basic information

• Product Name: N-[3-(hydroxymethyl)phenyl]acetamide
• CAS NO: 16375-94-3
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.1891
• Mol File: 16375-94-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 395°C at 760 mmHg
• Flash Point: 192.7°C
• Density: 1.211g/cm³
• Vapor Pressure: 5.99E-07mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: N-[3-(hydroxymethyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(hydroxymethyl)phenyl]acetamide(16375-94-3)
• EPA Substance Registry System: N-[3-(hydroxymethyl)phenyl]acetamide(16375-94-3)

Safety Data

• Hazardous Substances Data: 16375-94-3(Hazardous Substances Data)

Upstream product

• 2466-76-4 N-Acetylimidazole 
• 1877-77-6 3-aminobenzenemethanol 
• 59755-25-8 3-acetylaminobenzaldehyde 
• 619-25-0 3-Nitrobenzyl alcohol 
• 141-78-6 ethyl acetate 
• 99-61-6 3-nitro-benzaldehyde 
• 108-24-7 acetic anhydride 
• 123306-28-5 N-(3-formylphenyl)acetamide 
• 1120232-05-4 BF₄^(1-)*C₇H₇N₂O⁽¹⁺⁾ 
• 75-05-8 acetonitrile 
• 75-36-5 acetyl chloride 

Downstream Products

• 59755-25-8 3-acetylaminobenzaldehyde 
• 1401067-64-8 N-(3-(hydroxy(2-nitrophenyl)methyl)phenyl)acetamide 
• 1033780-15-2 (E)-N-[1-(3-acetylamino-benzyl)-1H-pyrazol-3-yl]-2-(3-chloro-4-methanesulfonyl-phenyl)-2-cyclopentyloxyimino-acetamide 
• 1033780-32-3 N-[3-(3-nitro-pyrazol-1-ylmethyl)-phenyl]-acetamide 
• 1033780-33-4 N-[3-(3-amino-pyrazol-1-ylmethyl)-phenyl]-acetamide 
• 82772-22-3 N-(3-formylphenyl)-N-methylacetamide 
• 1338532-84-5 2-(meta-acetamidophenyl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole 3-oxide 1-oxyl 
• 1338532-81-2 C₁₅H₂₃N₃O₃ 
• 408507-75-5 N-(3-cyanomethyl-phenyl)-acetamide 
• 90914-80-0 N-(3-(bromomethyl)phenyl)acetamide 
• 90942-40-8 acetic acid-(3-chloromethyl-anilide) 

Relevant articles and documents

Practical Chemoselective Acylation: Organocatalytic Chemodivergent Esterification and Amidation of Amino Alcohols with N-Carbonylimidazoles

Chemoselective transformations are a cornerstone of efficient organic synthesis; however, achieving this goal for even simple transformations, such as acylation reactions, is often a challenge. We report that N-carbonylimidazoles enable catalytic chemodivergent aniline or alcohol acylation in the presence of pyridinium ions or 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), respectively. Both acylation reactions display high and broad chemoselectivity for the target group. Unprecedented levels of chemoselectivity were observed in the DBU-catalyzed esterification: A single esterification product was obtained from a molecule containing primary aniline, alcohol, phenol, secondary amide, and N?H indole groups. These acylation reactions are highly practical as they involve only readily available, inexpensive, and relatively safe reagents; can be performed on a multigram scale; and can be used on carboxylic acids directly by in situ formation of the acylimidazole electrophile.

Chemoselective reduction of nitroarenes, N-acetylation of arylamines, and one-pot reductive acetylation of nitroarenes using carbon-supported palladium catalytic system in water

Developing and/or modifying fundamental chemical reactions using chemical industry-favorite heterogeneous recoverable catalytic systems in the water solvent is very important. In this paper, we developed convenient, green, and efficient approaches for the chemoselective reduction of nitroarenes, N-acetylation of arylamines, and one-pot reductive acetylation of nitroarenes in the presence of the recoverable heterogeneous carbon-supported palladium (Pd/C) catalytic system in water. The utilize of the simple, effective, and recoverable catalyst and also using of water as an entirely green solvent along with relatively short reaction times and good-to-excellent yields of the desired products are some of the noticeable features of the presented synthetic protocols. Graphic abstract: [Figure not available: see fulltext.].

SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.