82804-53-3Relevant academic research and scientific papers
Generation of Benzyne Species from Diphenylphosphoryl Derivatives: Simultaneous Exchange of Three Functional Groups
Gorobets, Evgueni,Parvez, Masood,Derksen, Darren J.,Keay, Brian A.
, p. 8479 - 8482 (2016)
Interaction of (2-diphenylphosphoryl-3-iodo-4-methoxy-phenyl) methanol with NaH in DMF at ambient temperature results in the generation of benzyne intermediates that can be trapped by furan or DMF. Trapping with DMF forms 3-(dimethylaminomethyl)-2-hydroxy-6-methoxybenzaldehyde demonstrating the simultaneous exchange of three functionalities in a single step. The presence of the alkoxy substituent adjacent to iodine is critical for high regioselectivity addition of DMF. The corresponding bromide or triflate can be used in place of the iodide with equal efficiency. This methodology was used to synthesize the reported structure of gigasol and leading to a structural reassignment of this biscoumarin natural product.
1 -HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS
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, (2014/10/03)
Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula:A typical example for a compound according to above formula is: A typical example for a compound according to above formula is:
Bromination with Concomitant Debenzylation of Some Aromatic Aldehydes Containing Benzyloxy Substituents
Natarajan, S.,Rajeswari, S.,Chandrasekaran, S.,Pai, B. R.,Shanmuganathan, Sp.,Rao, K. Usha
, p. 95 - 97 (2007/10/02)
During the study of bromination of m-benzyloxybenzaldehyde with bromine in carbon tetrachloride at room temperature, it has been observed that besides bromination concomitant debenzylation also occurs.This being a novel observation, the study has been extended to 3-benzyloxy-4-methoxy-, 2-benzyloxy-3-methoxy-, 3,4-dibenzyloxy- and 4-benzyloxy-3-methoxy-benzaldehydes.In all but the last case, ready debenzylation with bromination occurs.Thus, the essential requirement for debenzylation is that the benzyl ether group should be either meta or ortho to the aldehydic function.The orientation of substituents in the reaction products has been determined by PMR and UV spectral studies.
