828261-34-3Relevant academic research and scientific papers
Conformational studies of 4-N-carbamoyldeoxycytidine derivatives and synthesis and hybridization properties of oligodeoxyribonucleotides incorporating these modified bases
Miyata, Kenichi,Kobori, Akio,Tamamushi, Ryuji,Ohkubo, Akihiro,Taguchi, Haruhiko,Seio, Kohji,Sekine, Mitsuo
, p. 3626 - 3637 (2006)
Deoxycytidine derivatives modified with various N-substituted carbamoyl groups at the 4-amino group were synthesized. The detailed 1H NMR studies suggest that the 3′,5′-O-disilylated N- carbamoyldeoxycytidine derivative 11 exists as a species h
Synthesis of terminally modified oligonucleotides and their hybridization dependence on the size of the target RNAs
Seio, Kohji,Takaku, Yusuke,Miyazaki, Kazuya,Kurohagi, Sayako,Masaki, Yoshiaki,Ohkubo, Akihiro,Sekine, Mitsuo
experimental part, p. 2440 - 2451 (2009/09/26)
We have developed new artificial oligonucleotide probes that show selective recognition for short RNA targets over long RNA targets. Our results suggested that modification of the termini of the oligonucleotide probes by bulky substituents such as cyclohe
Synthesis and hybridization affinity of oligodeoxyribonucleotides incorporating 4-N-(N-arylcarbamoyl)deoxycytidine derivatives
Miyata, Kenichi,Tamamushi, Ryuji,Ohkubo, Akihiro,Taguchi, Haruhiko,Seio, Kohji,Sekine, Mitsuo
, p. 9365 - 9368 (2007/10/03)
Modified oligodeoxynucleotides incorporating 4-N-(N-arylcarbamoyl)-dC derivatives 1a-c were synthesized. The 1H NMR spectra of 1a-c suggest that the carbamoyl group forms an intramolecular hydrogen bond with the cytosine ring nitrogen atom so t
