82830-23-7Relevant academic research and scientific papers
Receptor-based design of dihydrofolate reductase inhibitors: Comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues
Kuyper,Roth,Baccanari,Ferone,Beddell,Champness,Stammers,Dann,Norrington,Baker
, p. 303 - 310 (2007/10/02)
By the use of molecular models of Escherichia coli dihydrofolate reductase (DHFR), analogues of trimethoprim (TMP) were designed which incorporated various 3'-carboxyalkoxy moieties in order to acquire ionic interactions with positively charged active-sit
