82850-01-9Relevant academic research and scientific papers
An efficient and simple strategy toward the synthesis of highly functionalized compounds
Jmai, Momtez,Efrit, Mohamed Lotfi,Dubreuil, Didier,Blot, Virginie,Lebreton, Jacques,M'rabet, Hédi
, p. 978 - 995 (2021/08/06)
The expedient syntheses of small libraries of ((β-ethoxycarbonyl, -cyano and -acetyl)propyloxy) methylphosphonate scaffolds bearing olefin, sulfanyl, or amine functions are described. All these new derivatives are readily produced from easily available starting reagents (aldehydes, electron-poor olefins, and dialkylphosphites) following a three steps reaction sequence of condensations, SN2′-type reaction and a conjugated thia- or aza-Michael 1,4-addition with aromatic and aliphatic thiol or amine nucleophiles.
Expedient Synthesis of Natural (S)-Sinefungin and of its C-6' Epimer
Barton, Derek H. R.,Gero, Stephane D.,Quiclet-Sire, Beatrice,Samadi, Mohammed
, p. 981 - 985 (2007/10/02)
Sinefungin 1a and 6-epi-sinefungin 1b have been prepared from adenosine and L-aspartic acid.The key step in the synthesis was the coupling of the radical derived from 14 with the unsaturated amide 13.The latter was obtained by a radical reaction from L-as
