82884-40-0Relevant academic research and scientific papers
ENANTIOSELECTIVE SYNTHESIS OF SILOXYCYCLOPROPANES AND OF γ-OXOCARBOXYLATES BY ASYMMETRIC CATALYSIS
Kunz, Thomas,Reissig, Hans-Ulrich
, p. 2079 - 2082 (2007/10/02)
Up to 48percent enantiomeric excess have been attained by cyclopropanation of silyl enol ethers with methyl diazoacetate in the presence of optically active Cu-catalysts.Subsequent ring opening of resulting siloxycyclopropanes gives γ-oxocarboxylates with
Synthesis of 2-Siloxy-substituted Methyl Cyclopropanecarboxylates
Kunkel, Elisabeth,Reichelt, Ingrid,Reissig, Hans-Ulrich
, p. 512 - 530 (2007/10/02)
2-Siloxy-substituted methyl cyclopropanecarboxylates C - useful building blocks in synthesis - are obtained in great variety and with good yields from the silyl enol ethers E and methyl diazoacetate (D) under copper salt catalysis.Whereas the regiochemical and stereochemical properties of E are completely transferred to the cyclopropanes C, the stereoselectivity concerning the position of the methoxycarbonyl group is low.The 1H and 13C data used to determine the configurations of compounds C are discussed.
