82891-77-8

Upstream product

• 766-84-7 3-chloro-benzonitrile 
• 141-43-5 ethanolamine 
• 535-80-8 3-chlorobenzoate 
• 587-04-2 m-Chlorobenzaldehyde 
• 15258-03-4 3-Chloro-N-(2-chloro-ethyl)-benzamide 
• 57728-64-0 3-Chloro-N-(2-hydroxy-ethyl)-benzamide 
• 618-46-2 m-Chlorobenzoyl chloride 

Downstream Products

• 24350-21-8 7-chloro-3-phenyl-1H-2-benzopyran-1-one 
• 57728-64-0 3-Chloro-N-(2-hydroxy-ethyl)-benzamide 
• 1119512-93-4 bis-(2-[m-chlorophenyl]-2-oxazoline-κ1N) zinc(II) chloride 
• 1119513-00-6 bis-(2-[m-chlorophenyl]-2-oxazoline-κ1N) zinc(II) bromide 
• 82891-90-5 2-(2-methyl-3-chlorophenyl)-2-oxazoline 
• 82891-78-9 2-Biphenyl-3-yl-4,5-dihydro-oxazole 
• 82891-81-4 2-(3-Propyl-phenyl)-4,5-dihydro-oxazole 
• 82891-80-3 2-(3-Ethyl-phenyl)-4,5-dihydro-oxazole 

Relevant academic research and scientific papers

Rhodium(III)-Catalyzed Oxidative Cyclization of Oxazolines with Cyclopropanols: Synthesis of Isoindolinones

The synthesis of C3-substituted isoindolin-1-ones from oxazolines and cyclopropanols has been achieved with oxazoline as a bifunctional nucleophilic directing group. The reaction proceeds by the cleavage of three chemical bonds and allows the formation of three new chemical bonds, a C-N bond, a C-C bond, and a C-O bond, in a single step.

Mild, Selective Ru-Catalyzed Deuteration Using D2O as a Deuterium Source

A method for the selective deuteration of polyfunctional organic molecules using catalytic amounts of [RuCl2(PPh3)3] and D2O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration process are observed. Mechanistic investigation indicates the presence of different, defined Ru-complexes under the given specific conditions.

A 2 - aryl - 2 - oxazoline preparation method

The invention discloses a 2-aryl-2-oxazoline preparation method and belongs to the field of chemistry. According to the method, an aryl-amide compound and 1,2-dichloroethane are reacted for synthesis, and the synthesis reaction is conducted under the alka

Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

A novel method for the synthesis of β-nitrate ester carboxamides using non-corrosive tert-butyl nitrite (TBN) as the nitro source and easily available oxygen as the oxidant has been developed. Variously substituted 2-oxazolines were efficiently ring-opened to deliver the corresponding products in excellent yields. Notably, this reaction provides fast access to pharmaceuticals such as nicorandil.

Willgerodt–Kindler reaction-driven one pot solventless entry to 2-oxazolines

We report an efficient and green protocol for the synthesis of 2-oxazolines by the reaction of aromatic nitriles with β-aminoalcohols using sulfur under solvent-free conditions. The reaction occurs via the Willgerodt-Kindler mechanism followed by transami

An efficient one-pot synthesis of 2-oxazolines with molecular iodine under ultrasound irradiation

A series of 2-oxazolines were prepared by the condensation of aldehydes with 2-aminoethanol in the presence of molecular iodine and potassium carbonate in t-BuOH at 35-40 °C under ultrasound irradiation. The easy work-up procedure and moderate to good yie

Trichloroisocyanuric acid as an efficient homogeneous catalyst for the chemoselective synthesis of 2-substituted oxazolines, imidazolines and thiazolines under solvent-free condition

Trichloroisocyanuric acid, as a commercially available and inexpensive catalyst, was used in a new, facile and efficient procedure for the synthesis of 2-oxazolines, 2-imidazolines and 2-thiazolines through the reaction of nitriles with 2-aminoethanol, ethylenediamine or 2-aminoethanethiol under solvent-free conditions.

An exploration of the metal oxide-assisted decomposition and rearrangement of VV-Acyl-1, 3-oxazolidin-2-ones leading to 2-Aryl-2-oxazolines [1]

An exploration into the utility of the thermally-induced (metal oxide-mediated) CO2 extrusion and subsequent rearrangement of N-acyl-1, 3-oxazolidin-2-ones to form 2-aryl(alkyl)-2-oxazolines is described. The reaction is found to give moderate yields of t

Preparation of an improved sulfonated carbon-based solid acid as a novel, efficient, and reusable catalyst for chemoselective synthesis of 2-oxazolines and bis-oxazolines

A highly sulfonated carbon as an efficient, recyclable, nontoxic, and green solid acid catalyst was readily synthesized by simultaneous sulfonation, dehydration, and carbonization of sucrose in sulfuric acid and was characterized by FT-IR, TG-DTG, XRD, and CHNS analysis, neutralization potentiometric titration, and SEM techniques. This new catalyst was used for preparation of 2-oxazolines and bis-oxazolines by reaction of β-aminoethanol with nitriles under reflux conditions. Sonication of this system enhanced the catalytic activity of the carbon-based solid acid and led to higher product yields and shorter reaction times. Another advantage of the system under ultrasonic irradiation is the ability to carry out large-scale reactions. In two cases, the catalyst was reused several times without loss of its activity.

A convenient synthesis of oxazolines and imidazolines from aromatic aldehydes with pyridinium hydrobromide perbromide in water

Various 2-oxazolines were prepared from aromatic aldehydes and 2-aminoethanol with pyridinium hydrobromide perbromide in water at room temperature. 2-Imidazolines were also obtained in good yields from aromatic aldehydes and ethylenediamine under the same reaction conditions. Georg Thieme Verlag Stuttgart.