24350-21-8

Basic information

• Product Name: 7-chloro-3-phenyl-1H-2-benzopyran-1-one
• Synonyms: 7-chloro-3-phenyl-1H-2-benzopyran-1-one
• CAS NO: 24350-21-8
• Molecular Weight: 256.688
• Mol File: 24350-21-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 7-chloro-3-phenyl-1H-2-benzopyran-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-3-phenyl-1H-2-benzopyran-1-one(24350-21-8)
• EPA Substance Registry System: 7-chloro-3-phenyl-1H-2-benzopyran-1-one(24350-21-8)

Safety Data

• Hazardous Substances Data: 24350-21-8(Hazardous Substances Data)

Upstream product

• 174265-12-4 2-bromo-5-chlorobenzaldehyde 
• 536-74-3 phenylacetylene 
• 1186603-47-3 5-chloro-2-(phenylethynyl)benzaldehyde 
• 27007-53-0 methyl-2-bromo-5-chlorobenzoate 
• 93-91-4 1-phenylbutan-1,3-dione 
• 98-86-2 acetophenone 
• 21739-93-5 2-bromo-5-chlorobenzoic acid 
• 120-46-7 1,3-diphenylpropanedione 
• 1382353-03-8 C₁₅H₁₀ClIO₂ 
• 124-38-9 carbon dioxide 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 535-80-8 3-chlorobenzoate 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 82891-77-8 2-(3-chlorophenyl)-4,5-dihydro-1,3-oxazole 

Relevant articles and documents

Rhodium catalyzed carbon-hydrogen bond activation reaction for synthesizing isocoumarin derivative

The invention belongs to the technical field of fine chemicals, and particularly relates to a preparation method of an isocoumarin derivative, and the isocoumarin derivative is a compound shown as a formula (I).

A aqueous phase catalytic cascade reaction in the synthesis of isocoumarin derivatives of the method (by machine translation)

The invention provides a method for the aqueous phase catalytic cascade reaction in the synthesis of isocoumarin derivatives of the method, which is based on the concentration in the aqueous phase is 0.1 — 1 mol/L of ortho-halo benzoic acid 1 μM with 0.1 μM — 5 μM terminal alkyne in of 0.001 μM — 1 μM catalyst bivalent copper salt and O-phenanthrene under the catalytic action of, in 0.5 μM — 6 μM inorganic base or organic base in the presence of, in 20o C — 160 o C lower reaction 1h — 50h one pot synthesis isocoumarin derivatives. The invention is an environment-friendly, the operation is simple, cheap and safe, efficient to prepare the isocoumarin compound of the novel method, compared with the prior art, not only can be applied to a large number of functional groups, but also with simple operation, high yield, single product, convenient separation and purification, safe and cheap, small pollution and the like. (by machine translation)

Palladium-Catalyzed Sequential Nucleophilic Addition/Oxidative Annulation of Bromoalkynes with Benzoic Acids to Construct Functionalized Isocoumarins

An efficient and robust protocol for the preparation of 3-substituted isocoumarins via palladium-catalyzed nucleophilic addition/oxidative annulation of bromoalkynes with benzoic acids has been developed. Remarkably, preliminary mechanistic studies indicated that the transformation might proceed via a stereo- and regioselective nucleophilic addition and C-H functionalization procedure.