82898-65-5Relevant academic research and scientific papers
Synthesis and Spin-Trapping Chemistry of 5,5-Dimethyl-2-(trifluoromethyl)-1-pyrroline N-Oxide
Janzen, Edward G.,Zhang, Young-Kang,Arimura, Masana
, p. 5434 - 5440 (1995)
A new five-membered ring nitrone, 5,5-dimethyl-2-(trifluoromethyl)-1-pyrroline N-oxide (2-TFDMPO), is synthesized for the purpose of spin trapping in free radical biology.Most of the spin adducts of 2-TFDMPO are persistent, and EPR, ENDOR, and MS spectra can be obtained.A variety of radicals give characteristic spectral signatures, among which is a rare type of line width alternation pattern due to hindered rotation of the trifluoromethyl group.
Nucleophilic trifluoromethylation of conjugate acceptors via phenyl trifluoromethyl sulfone
Sakavuyi, Kaumba,Petersen, Kimberly S.
supporting information, p. 6129 - 6132 (2013/10/22)
A mild procedure for the conjugate addition of the trifluoromethyl anion to activated Michael acceptors such as arylidenemalononitriles (15 examples) and arylidene Meldrum's acids (9 examples) using phenyl trifluoromethyl sulfone through a reductive magnesium metal mediated procedure is described. The new methodology is used to prepare befloxatone, a reversible and selective monoamine oxidase A inhibitor.
SYNTHESE DE LA TRIFLUOROMETHYL-VINYL-CETONE
Tordeux, M.,Wakselman, C.
, p. 301 - 306 (2007/10/02)
The synthesis of trifluoromethylvinylketone 6 is described.The metal hydride reduction of ethyl trifluoroacetoacetate 1 gives the glycol 2.Selective tosylation of 2 occurs on the primary hydroxyl group and leads to 3.Tosyl-chloride exchange produces the c
