Synthesis and Spin-Trapping Chemistry of 5,5-Dimethyl-2-(trifluoromethyl)-1-pyrroline N-Oxide

Article abstract of DOI:10.1021/jo00122a021

A new five-membered ring nitrone, 5,5-dimethyl-2-(trifluoromethyl)-1-pyrroline N-oxide (2-TFDMPO), is synthesized for the purpose of spin trapping in free radical biology.Most of the spin adducts of 2-TFDMPO are persistent, and EPR, ENDOR, and MS spectra can be obtained.A variety of radicals give characteristic spectral signatures, among which is a rare type of line width alternation pattern due to hindered rotation of the trifluoromethyl group.