829-43-6

Usage

Type of Compound

Ketone

Carbonyl Group

Bonded to two alkyl groups

Usage

Intermediate in the synthesis of pharmaceuticals and other organic compounds

Structure

Four-carbon chain with a methyl group attached to the third carbon and a 4-fluorophenyl group attached to the first carbon

Industrial Applications

Flavoring agent, perfuming ingredient

Potential Properties

Biological and pharmacological properties

Upstream product

• 1194-02-1 4-fluorobenzonitrile 
• 5674-02-2 2-methylpropylmagnesium chloride 
• 108-64-5 Ethyl isovalerate 
• 147356-77-2 N-methoxy-N,3-dimethylbutanamide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 71370-05-3 4-methyl-2-phenylpent-4-en-2-ol 
• 459-57-4 4-fluorobenzaldehyde 
• 462-06-6 fluorobenzene 
• 108-12-3 isopentanoyl chloride 

Downstream Products

• 2285-92-9 α-<4-Fluor-phenyl>-isopentylamin 
• 1443251-49-7 3-(4-fluorophenyl)-3-isobutyl-4,5,6,7-tetrahydrofuro[3,4-c]pyridin-1(3H)-one 
• 1443250-89-2 3-(4-fluorophenyl)-3-isobutyl-5-(3-(piperidin-1-yl)propanoyl)-4,5,6,7-tetrahydrofuro[3,4-c]pyridin-1(3H)-one 
• 1443251-48-6 3-(4-fluorophenyl)-3-isobutylfuro[3,4-c]pyridin-1(3H)-one 

Relevant academic research and scientific papers

Photocatalyzed Triplet Sensitization of Oximes Using Visible Light Provides a Route to Nonclassical Beckmann Rearrangement Products

Oximes are valuable synthetic intermediates for the preparation of a variety of functional groups. To date, the stereoselective synthesis of oximes remains a major challenge, as most current synthetic methods either provide mixtures of E and Z isomers or furnish the thermodynamically preferred E isomer. Herein we report a mild and general method to achieve Z isomers of aryl oximes by photoisomerization of oximes via visible-light-mediated energy transfer (EnT) catalysis. Facile access to (Z)-oximes provides opportunities to achieve regio- and chemoselectivity complementary to those of widely used transformations employing oxime starting materials. We show an enhanced one-pot protocol for photocatalyzed oxime isomerization and subsequent Beckmann rearrangement that enables novel reactivity with alkyl groups migrating preferentially over aryl groups, reversing the regioselectivity of the traditional Beckmann reaction. Chemodivergent N- or O- cyclizations of alkenyl oximes are also demonstrated, leading to nitrones or cyclic oxime ethers, respectively.

COMPOSITION AND METHOD FOR NEUROPEPTIDE S RECEPTOR (NPSR) ANTAGONISTS

Neuropeptide S receptor antagonists are provided that bind in functional assays to neuropeptide S receptors; methods are provided for use of these antagonists in treatment of conditions or disease states that are ameliorated by blocking of the neuropeptide S receptor, including substance abuse and substance abuse relapse; and for use of neuropeptide S receptor antagonists in the manufacture of therapeutics and pro-drugs for therapeutics useful in disease states and conditions sensitive to binding of the neuropeptide S receptor.

A heterogeneous Ru/CeO2 catalyst effective for transfer-allylation from homoallyl alcohols to aldehydes

A simple heterogeneous Ru/CeO2 catalyst was found to be effective for transfer-allylation from homoallyl alcohols to aldehydes, followed by isomerization to give the saturated ketones in high yields.