829-58-3

Upstream product

• 141-82-2 malonic acid 
• 824-54-4 2-bromo-4-methylbenzaldehyde 
• 583-68-6 2-bromo-p-toluidine 

Downstream Products

• 876-91-5 4-bromo-6-methyl-2,3-dihydro-1H-inden-1-one 
• 829-57-2 3-(2-bromo-4-methylphenyl)propanoic acid 

Relevant academic research and scientific papers

1,4-Palladium Shift/C(sp3)-H Activation Strategy for the Remote Construction of Five-Membered Rings

1,n-Metal shift is an elegant alternative approach enabling the functionalization of remote C-H bonds from simple precursors. In this work, we report a novel and simple Pd0-catalyzed domino reaction involving 1,4-palladium shift and C(sp3)-H activation and leading to (fused) five-membered rings. This method allowed access to a broad range of valuable arylidene γ-lactams and indanones and was applied to the formal synthesis of (-)-pyrrolam.