82900-57-0 Usage
Uses
BP 554 Maleate was used to study the methods for the classification and diagnosis of scoliosis.
Biological Activity
Selective 5-HT 1A agonist.
references
[1]. matsuda t, seong yh, aono h, et al. agonist activity of a novel compound, 1-[3-(3,4-methylenedioxyphenoxy)propyl]-4-phenyl piperazine (bp-554), at central 5-ht1a receptors. eur j pharmacol, 1989, 170(1-2): 75-82. [2]. galter d, unsicker k. sequential activation of the 5-ht1(a) serotonin receptor and trkb induces the serotonergic neuronal phenotype. mol cell neurosci, 2000, 15(5): 446-455.[3]. rauch a, rainer g, logothetis nk. the effect of a serotonin-induced dissociation between spiking and perisynaptic activity on bold functional mri. proc natl acad sci u s a, 2008, 105(18): 6759-6764.
Check Digit Verification of cas no
The CAS Registry Mumber 82900-57-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,9,0 and 0 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 82900-57:
(7*8)+(6*2)+(5*9)+(4*0)+(3*0)+(2*5)+(1*7)=130
130 % 10 = 0
So 82900-57-0 is a valid CAS Registry Number.
InChI:InChI=1/C20H24N2O3/c1-2-5-17(6-3-1)22-12-10-21(11-13-22)9-4-14-23-18-7-8-19-20(15-18)25-16-24-19/h1-3,5-8,15H,4,9-14,16H2
82900-57-0Relevant articles and documents
Discovery of LASSBio-772, a 1,3-benzodioxole N-phenylpiperazine derivative with potent alpha 1A/D-Adrenergic receptor blocking properties
Romeiro, Luiz A.S.,Da Silva Ferreira, Marcos,Da Silva, Leandro L.,Castro, Helena C.,Miranda, Ana L.P.,Silva, Cláudia L.M.,No?l, Franois,Nascimento, Jéssica B.,Araújo, Claudia V.,Tibiri?á, Eduardo,Barreiro, Eliezer J.,Fraga, Carlos A.M.
, p. 3000 - 3012 (2011/07/08)
We described herein the discovery of 1-(2-(benzo[d] [1,3]dioxol-6-yl)ethyl) -4-(2-methoxyphenyl) piperazine (LASSBio-772), as a novel potent and selective alpha 1A/1D adrenoceptor (AR) antagonist selected after screening of functionalized N-phenylpiperazine derivatives in phenylephrine-induced vasoconstriction of rabbit aorta rings. The affinity of LASSBio-772 for alpha 1A and alpha 1B AR subtypes was determined through displacement of [ 3H]prazosin binding. We obtained Ki values of 0.14 nM for the alpha 1A-AR, similar to that displayed by tamsulosin (Ki = 0.13 nM) and 5.55 nM for the alpha 1B-AR, representing a 40-fold higher affinity for alpha 1A-AR. LASSBio-772 also presented high affinity (KB = 0.025 nM) for the alpha 1D-AR subtype in the functional rat aorta assay, showing to be equipotent to tamsulosin (KB = 0.017 nM).
