82928-10-7Relevant academic research and scientific papers
SUBSTITUTED 2H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS GSK-3 INHIBITORS
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Page/Page column 29, (2010/02/11)
The invention relates to compounds of formula (I) prodrugs thereof, and the pahrmaceutically acceptabel salts of the compounds and prodrugs, wherein Ra, Rb, R1 and R2 are as defined herein; pharmaceutical compositions thereof; and uses thereof.
Substituted 4-amino[1,2,4]triazolo[4,3-a] quinoxalines
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Page/Page column 12, (2010/02/08)
The present invention provides compounds of formula (I) the prodrugs thereof, and the pharmaceutically acceptable salts of the compounds and prodrugs, wherein Ra, Rb, R1, and R2 are as defined herein; pharmaceutical compositions thereof; and uses thereof.
An approach to the design of brain-penetrating histaminergic agonists
Young,Ganellin,Griffiths,Mitchell,Parsons,Saunders,Sore
, p. 201 - 211 (2007/10/02)
Known and novel histaminergic H1- and H2-receptor agonists were investigated as potentially potent and selective brain-penetrating compounds. Structural modifications were introduced in an attempt to favour passive diffusion across t
