82933-21-9Relevant academic research and scientific papers
Demonstration of Exclusive α-Peptidation at the Micellar Interface
Ranganathan, Darshan,Ranganathan, Subramania,Singh, Girij Pal,Patel, Bhisma Kumar
, p. 525 - 528 (2007/10/02)
Microreactors, dispersed in iso-octane, harboring water pools and crafted from AOT and co-surfactant condensing agent DODCI, exclusively direct α-peptidation, thus reversing the normal preference of glutamic acid and aspartic acid for side chain carboxyl group amidation.
The transformation of histidine side chain to non-coded asparagines
Ranganathan, Subramania,Ranganathan, Darshan,Bhattacharyya, Dipti
, p. 5615 - 5618 (2007/10/02)
The transformation of the histidine side chain to that of Nω-carbamoyl asparagine, Nω-formyl asparagine, Nω-benzoyl asparagine, β-cyano alanine and aspartic acid has been described, involving as the primary step, the Ru(VI
L-METHIONINE OXIDATION: NOVEL AND UNANTICIPATED TRANSFORMATIONS WITH 4-tBUTYL IODOXYBENZENE
Ranganathan, S.,Ranganathan, D.,Singh, S.K.,Bhattacharyya, D.,Shanthy, S.,Singh, G.P.
, p. 5363 - 5366 (2007/10/02)
4-tButyl iodoxybenzene transforms Bz-Met-OMe to products arising from, S oxidation and C-H insertion followed by degradation.Z-Met(sulfoxide)-OMe is very effective in bringing about ester hydrolysis via intramolecular attack.The S oxidation to sulfoxides and then to sulfones can be monitored and controlled, proceeds with chiral retention, affects neither the peptide bond nor the protecting groups and has been further illustrated with,Z-Gly-Met-OMe, Z-Met-OMe and Z-S(benzyl)-Cys-OMe.
The Transformation of Tryptophan to Aspartic Acid in Peptides
Ranganathan, Subramania,Ranganathan, Darshan,Bhattacharyya, Dipti
, p. 1085 - 1086 (2007/10/02)
The tryptophan side chain is transformed by in situ generated ruthenium(VIII), to that of aspartic acid, in good yields; amulti-step degradation sequence is suggested on the basis of the transformations of tetrahydrocarbazole to adipic acid, valine to isobutyric acid, and phenylalanine to phenylacetic acid.
