82933-25-3Relevant articles and documents
Practical synthetic approaches to intermediates for the preparations of the novel O-sulfonated-N-hydroxy-2-azetidinone antibiotics
Miller,Biswas,Krook
, p. 2571 - 2575 (1983)
A practical synthesis of intermediates useful for the preparation of a variety of monocyclic β-lactam antibiotics is described. Hydroxaminolysis of N-protected serine esters provided the hydroxamic acids 10. Acylation followed by cyclization yielded the β
O-sulfated β-lactam hydroxamic acids and intermediates
-
, (2008/06/13)
Antibacterial activity is exhibited by β-lactams having a sulfate substituent in the 1-position and an acylamino substituent in the 3-position.