Practical synthetic approaches to intermediates for the preparations of the novel O-sulfonated-N-hydroxy-2-azetidinone antibiotics

Article abstract of DOI:10.1016/S0040-4020(01)92150-7

A practical synthesis of intermediates useful for the preparation of a variety of monocyclic β-lactam antibiotics is described. Hydroxaminolysis of N-protected serine esters provided the hydroxamic acids 10. Acylation followed by cyclization yielded the β