82946-71-2Relevant academic research and scientific papers
Nickel-catalyzed reductive defunctionalization of esters in the absence of an external reductant: Activation of C-O bonds
Iyori, Yasuaki,Takahashi, Kenjiro,Yamazaki, Ken,Ano, Yusuke,Chatani, Naoto
supporting information, p. 13610 - 13613 (2019/11/14)
The nickel-catalyzed reductive cleavage of esters in the absence of an external reductant, which involves the cleavage of an inert acyl C-O bond in O-Alkyl esters is reported. Various groups, such as N-containing heterocycles, esters, amides, and even arene rings can function as a directing group.
Tandem Additions of Cuprates to Benzynes. A Regioselective Synthesis of 3-Alkyl or Aryl-2-substituted Benzoic Acids
Meyers, A. I.,Pansegrau, Paul D.
, p. 690 - 691 (2007/10/02)
Organocuprates add to benzyne (2), generated in situ, to give regiospecific aromatic substitution products.
THE SYNTHESIS OF 1,2,3-TRISUBSTITUTED BENZENES. FURTHER COMMENTS ON BENZYNES DERIVED FROM ARYL OXAZOLINES
Meyers, A. I.,Pansegrau, Paul D.
, p. 4935 - 4938 (2007/10/02)
Further investigation of organolithium addition to the 2,3-benzyne of aryl oxazolines reveals that addition takes place to give the 3-lithio (kinetic) and/or 2-lithio (thermodynamic) products depending on the nature of the organolithium reagent.
BENZYNE DERIVED FROM ARYLOXAZOLINES. A VERSATILE INTERMEDIATE.
Meyers, A. I.,Rieker, William
, p. 2091 - 2094 (2007/10/02)
The benzyne derived from m-chlorophenyl oxazoline adds nucleophiles regiospecifically producing m-substituted products.Electrophiles are also trapped furnishing 1,2,3-trisubstituted benzenes.
