80762-49-8

Upstream product

• 701923-86-6 3-Chloro-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzamide 
• 535-80-8 3-chlorobenzoate 
• 27644-80-0 2-(3-chloro-phenyl)-4,4-dimethyl-oxazolidine 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 30093-99-3 4,4-dimethyl-2-oxazoline 
• 625-99-0 3-iodochlorobenzene 
• 618-46-2 m-Chlorobenzoyl chloride 

Downstream Products

• 82946-66-5 4,4-Dimethyl-2-(11-oxa-tricyclo[6.2.1.0^2,7]undeca-2⁽⁷⁾,3,5,9-tetraen-3-yl)-4,5-dihydro-oxazole 
• 82946-74-5 4,4-dimethyl-2-(3-(thiophen-2-yl)phenyl)-4,5-dihydrooxazole 
• 93340-18-2 3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-pentyl-benzonitrile 
• 93340-17-1 3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-isopropyl-benzonitrile 
• 93340-38-6 3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-isobutyl-benzonitrile 
• 19312-06-2 4,5-dihydro-4,4-dimethyl-2-phenoxazole 
• 89393-44-2 2-(2-sec-Butyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 115890-77-2 [2-Butyl-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-phenyl-methanone 
• 98531-77-2 [2-Butyl-6-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-phenyl-methanone 
• 98531-79-4 [3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-2-yl]-phenyl-methanone 
• 115890-78-3 2-Butyl-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-N-phenyl-benzamide 
• 115890-97-6 1-[2-Butyl-6-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-ethanone 
• 98531-76-1 2-(2-Allyl-3-butyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 115890-74-9 2-Butyl-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-benzaldehyde 

Relevant academic research and scientific papers

The Winding Road towards an Atropo-enantioselective ‘ARYNE Coupling’

For the first time, the challenging atropo-enantioselective coupling of in-situ generated arynes and aryllithiums in the presence of a chiral ligand of lithium was investigated. This preliminary study demonstrates the feasibility of this concept, by affording enantioenriched axially chiral biaryls even in the case of products showing a high degree of steric congestion around the newly created aryl?aryl bond.

Photoinduced Copper-Catalyzed C-H Arylation at Room Temperature

Room-temperature azole C-H arylations were accomplished with inexpensive copper(I) compounds by means of photoinduced catalysis. The expedient copper catalysis set the stage for site-selective C-H arylations of non-aromatic oxazolines under mild reaction conditions, and provides step-economical access to the alkaloid natural products balsoxin and texamine. Copper light: Room-temperature C-H arylations of heteroarenes were accomplished with inexpensive copper compounds by photoinduced catalysis. The expedient copper catalysis leads to site-selective C-H arylations of non-aromatic oxazolines under mild reaction conditions, and provides step-economical access to the alkaloid natural products balsoxin and texamine.

Directed functionalization of halophenyl-2-oxazolines with TMPMgCl?LiCl

A variety of difunctionalized aryl-2-oxazolines were prepared from the reaction of halophenyl-2-oxazolines and TMPMgCl?LiCl to give an organomagnesium reagent, which was then treated with various electrophiles. The metalation step takes place under mild conditions, and this process al-lows for the isolation of the desired products in good yields. No isomeric or other benzyne-derived products were detected. The influence of the halogen substituents on the acidity of the aromatic hydrogen atoms was evaluated by using density functional theory (DFT) calculations.