82959-00-0Relevant academic research and scientific papers
HOMOENOLATE DIANIONS OF SECONDARY AMIDES VIA TIN/LITHIUM EXCHANGE
Goswami, Ramanuj,Corcoran, Daniel E.
, p. 1463 - 1466 (2007/10/02)
Treatment of N-phenyl- as well as N-methyl-3-(tri-n-butylstannyl)-propionamide with 2 equiv of n-butyllithium in the presence of 1,4-diazabicyclooctane at -78 deg C in tetrahydrofuran produced the corresponding dilithio derivatives (homoenolate dianions) 4 and 8 respectively.Reaction with various electrophiles (1 equiv) gave the terminally substituted amides in good yields.
