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CAS

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82964-04-3

Tolrestat is a long-acting aldose reductase inhibitor, which is reportedly useful in the prophylaxis of diabetic neuropathy, retinopathy, and cataracts. It has been shown to decrease galactitol and sorbitol accumulation in various rat models, as well as reduce urinary total protein excretion in a rat model of diabetes induced by streptozotocin.
Used in Pharmaceutical Industry:
Tolrestat is used as an aldose reductase inhibitor for the prevention and treatment of diabetic complications such as neuropathy, retinopathy, and cataracts. Its ability to decrease the accumulation of galactitol and sorbitol in nerve tissues and lens, as well as reduce urinary total protein excretion, makes it a promising candidate for managing these conditions in diabetic patients.
Used in Ophthalmology:
Tolrestat is used as a prophylactic agent for cataract formation in patients with diabetes. Topical administration of Tolrestat has been shown to decrease levels of galactitol in the lens and inhibit cataract formation in rats fed a high-galactose diet, indicating its potential use in preventing cataract development in diabetic patients.
Note: The term "Alredase" mentioned in the provided materials does not seem to be related to Tolrestat. It might be a typo or an unrelated term.

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  • 82964-04-3 Structure

  • Basic information

    1. Product Name: TOLRESTAT
    2. Synonyms: TOLRESTAT;TolrestattolrestattolrestatTolrestat;TOLRESTAT(FORR&DONLY);Alredase;AY-27773;Lorestat;N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine;Tolrestatin
    3. CAS NO:82964-04-3
    4. Molecular Formula: C16H14F3NO3S
    5. Molecular Weight: 357.35
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 82964-04-3.mol

  • Chemical Properties

    1. Melting Point: 164-165°
    2. Boiling Point: 498.1 °C at 760 mmHg
    3. Flash Point: 255 °C
    4. Appearance: /
    5. Density: 1.399 g/cm3
    6. Vapor Pressure: 9.69E-11mmHg at 25°C
    7. Refractive Index: 1.601
    8. Storage Temp.: 2-8°C
    9. Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
    10. PKA: 3.49±0.10(Predicted)
    11. CAS DataBase Reference: TOLRESTAT(CAS DataBase Reference)
    12. NIST Chemistry Reference: TOLRESTAT(82964-04-3)
    13. EPA Substance Registry System: TOLRESTAT(82964-04-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 82964-04-3(Hazardous Substances Data)

82964-04-3 Usage

Originator

American Home Products (USA)

Biochem/physiol Actions

Tolrestat is considered to be effective in treating the consequences of diabetes including neuropathy, nephropathy, retinopathy and esophageal motility and vibration perception. Tolrestat is also believed to have lesser or no toxic effects.

Check Digit Verification of cas no

The CAS Registry Mumber 82964-04-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,9,6 and 4 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 82964-04:
(7*8)+(6*2)+(5*9)+(4*6)+(3*4)+(2*0)+(1*4)=153
153 % 10 = 3
So 82964-04-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22)

82964-04-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name tolrestat

1.2 Other means of identification

Product number -
Other names TOLRESTAT

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:82964-04-3 SDS

82964-04-3Relevant articles and documents

USE OF SUBSTITUTED 2 PHENYLBENZIMIDAZOLES AS MEDICAMENTS

-

, (2008/06/13)

The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R 4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula

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