82965-44-4

Basic information

• Product Name: 2,4-Xylenol, 6-chloro-alpha(sup 4)-(dimethylamino)-
• Synonyms: 2,4-Xylenol, 6-chloro-alpha(sup 4)-(dimethylamino)-
• CAS NO: 82965-44-4
• Molecular Formula: C₁₀H₁₄ClNO
• Molecular Weight: 199.67726
• Mol File: 82965-44-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 259.9°Cat760mmHg
• Flash Point: 111°C
• Appearance: /
• Density: 1.156g/cm³
• Vapor Pressure: 0.00779mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: 2,4-Xylenol, 6-chloro-alpha(sup 4)-(dimethylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Xylenol, 6-chloro-alpha(sup 4)-(dimethylamino)-(82965-44-4)
• EPA Substance Registry System: 2,4-Xylenol, 6-chloro-alpha(sup 4)-(dimethylamino)-(82965-44-4)

Safety Data

• Hazardous Substances Data: 82965-44-4(Hazardous Substances Data)

Usage

Type

Chlorinated derivative of 2,4-Xylenol

Function

Antimicrobial agent

Applications

Personal care products, household products (soaps, lotions, cleaning agents)

Antimicrobial Properties

Effective against a wide range of bacteria and fungi

Constituent Groups

Chloro group (6-chloro)
Dimethylamino group

Health Risks

Potential health risks necessitate careful regulation and monitoring

Environmental Risks

Environmental impact requires proper disposal and management

InChI:InChI=1/C10H14ClNO/c1-7-4-8(6-12(2)3)5-9(11)10(7)13/h4-5,13H,6H2,1-3H3

Upstream product

• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 
• 87-64-9 2-chloro-6-methylphenol 

Downstream Products

• 920509-14-4 (3-chloro-4-hydroxy-5-methylphenyl)acetic acid methyl ester 
• 920509-16-6 [3-chloro-4-(6-chloro-5-isopropylpyridazin-3-yloxy)-5-methylphenyl]acetic acid 
• 920509-15-5 [3-chloro-4-(6-chloro-5-isopropylpyridazin-3-yloxy)-5-methylphenyl]acetic acid methylester 
• 920509-13-3 (3-chloro-4-hydroxy-5-methylphenyl)acetic acid 
• 920509-12-2 (3-chloro-4-hydroxy-5-methylphenyl)acetonitrile 

Relevant articles and documents

Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3- yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia

The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). A pyridazinone series has been identified that is significantly more THR-β selective than earlier analogues. Optimization of this series by the addition of a cyanoazauracil substituent improved both the potency and selectivity and led to MGL-3196 (53), which is 28-fold selective for THR-β over THR-α in a functional assay. Compound 53 showed outstanding safety in a rat heart model and was efficacious in a preclinical model at doses that showed no impact on the central thyroid axis. In reported studies in healthy volunteers, 53 exhibited an excellent safety profile and decreased LDL cholesterol (LDL-C) and triglycerides (TG) at once daily oral doses of 50 mg or higher given for 2 weeks.