82979-45-1 Usage
Uses
Used in Pharmaceutical Industry:
Methyl 2-chloro-2-cyclopropylideneacetate is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of various pharmaceutical compounds and bioactive molecules. Its unique cyclopropyl group and reactivity make it a valuable component in the creation of new drugs.
Used in Agrochemical Industry:
Methyl 2-chloro-2-cyclopropylideneacetate is used as an intermediate in the synthesis of agrochemicals, where it plays a crucial role in the development of pesticides and other agricultural chemicals. Its properties allow for the creation of effective and targeted agrochemicals.
Used in Asymmetric Catalysis:
Methyl 2-chloro-2-cyclopropylideneacetate is used as a chiral ligand in asymmetric catalysis, a technique that is essential for the production of enantiomerically pure compounds. Its chiral properties make it a valuable tool in the synthesis of complex molecules with specific stereochemistry.
Used in Organic Synthesis:
Methyl 2-chloro-2-cyclopropylideneacetate is used as a versatile building block in organic synthesis, enabling the preparation of a wide range of compounds. Its reactivity and functional groups make it a key component in the synthesis of various organic molecules, including pharmaceuticals and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 82979-45-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,9,7 and 9 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 82979-45:
(7*8)+(6*2)+(5*9)+(4*7)+(3*9)+(2*4)+(1*5)=181
181 % 10 = 1
So 82979-45-1 is a valid CAS Registry Number.
82979-45-1Relevant articles and documents
Cyclopropyl building blocks for organic synthesis, part 100.[?] Advanced syntheses of cyclopropylideneacetates - Versatile multifunctional building blocks for organic synthesis
Limbach, Michael,Dalai, Suryakanta,De Meijere, Armin
, p. 760 - 766 (2007/10/03)
A well reproducible and inexpensive preparation of the cyclopropylideneacetates 2-4 has been developed. The key intermediate 2-(1′-mesyloxycyclopropyl)acetic acid (8), produced either from methyl phenylacetate (1) or 3,3-dimethoxypropionate (5-Me) and 3,3-diethoxypropionate (5-Et) in a sequence of Kulinkovich reductive cyclopropanation, mesylation and oxidative cleavage or cleavage and oxidation, respectively, was either converted to the benzyl ester 11b, or chlorinated (brominated) via the in situ formed acid chloride. The α-chloro- 12a and α-bromo ester 12b were dehydromesylated by treatment with triethylamine to furnish methyl 2-chloro-2-cyclopropylideneacetate (3-Me) and the 2-bromo analogue 4-Me with an overall yield of 68% (65%, 68%) and 52% (49%, 51%) respectively, starting from 1 (5-Me, 5-Et). The parent benzyl cyclopropylideneacetate 2-Bn was obtained by dehydromesylation of 11b with potassium t-butoxide in t-butyl methyl ether with an overall yield of 60% (57%, 9%) from 1 (5-Me, 5-Et).
A Convenient General Access to Methyl 2-Chloro-2-cyclopropylidenacetates, Reactive Michael Acceptors and Cycloaddends
Liese, Thomas,Teichmann, Stephan,Meijere, Armin de
, p. 25 - 32 (2007/10/02)
The reaction of 1-chloro-1-(trichlorovinyl)cyclopropanes 1 with potassium hydroxide/methanol or sodium methoxide/methanol yields trimethyl 2-chloro-2-cyclopropylidenorthoacetates 7, which can be quantitatively converted to the corresponding esters 8 by ac
