82995-92-4

Upstream product

• 82892-58-8 6-(phenylthio)-2-N-(phenylthiocarbonyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 20194-18-7 sodium phenyl-methanolate 
• 83005-49-6 2-<(methoxycarbonyl)amino>-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-phenylthiopurine 
• 51549-35-0 3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 82995-88-8 9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)-2-amino>purine 

Downstream Products

• 82892-81-7 C₆₉H₆₂ClN₁₀O₁₄P 
• 82892-73-7 C₆₉H₆₂ClN₁₀O₁₄P 
• 82892-70-4 5'-O-(4-chlorophenoxyacetyl)-6-O-benzyl-2-N-(benzyloxycarbonyl)-2'-deoxyguanosine 
• 82892-59-9 6-O-benzyl-2-N-(benzyloxycarbonyl)-2'-deoxyguanosine 

Relevant academic research and scientific papers

Synthesis of Benzyl and Benzyloxycarbonyl Base-Blocked 2'-Deoxyribonucleosides

Acylimidazoles have been alkylated with trialkyloxonium tetrafluoroborates to form acylimidazolium salts.These salts, particularly (benzyloxycarbonyl)imidazolium salts, are shown to be effective agents for the direct, mono-N-protection of deoxynucleosides as their acyl derivatives.These acyl nucleosides are also available via thiocarbamate intermediates.Thus 3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine (4b), on treatment with phenyl chlorothioformate, gave the 6-thiophenyl-substituted purine 38a.The thiophenyl group of 38a can be replaced by hydrogen, amino, and alkoxy groups to give a variety of substituted purine deoxyribonucleosides.

Synthesis of Oligodeoxyribonucleotides Using N-Benzyloxycarbonyl-Blocked Nucleosides

The exo amino groups of 2'-deoxyadenosine and 2'-deoxycytidine have been blocked as the benzyl carbamates, and 2'-deoxyguanosine has been blocked as its 2-N-(benzyloxycarbonyl)carbamate and 6-O-benzyl ether.These blocked nucleosides have been incorporated