830-52-4

Upstream product

• 60-29-7 diethyl ether 
• 77-78-1 dimethyl sulfate 
• 1131-01-7 2-chloro-N-(2,6-dimethylphenyl)acetamide 
• 767-71-5 N-methyl-2,6-dimethylaniline 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 110700-09-9 <<(2,6-Dimethylphenyl)methylcarbamoyl>methyl>triphenylphosphonium-chlorid 
• 110700-15-7 N-(2,6-Dimethylphenyl)-N-methyl-2,3-butadienamid 
• 53984-94-4 2-amino-N-methyl-2',6'-acetoxylidide 
• 121525-46-0 N-(2,6-Dimethylphenyl)-3--4-(diphenylmethylen)-N-methyl-2,2-diphenylcyclobutancarboxamid 
• 121525-45-9 N-(2,6-Dimethylphenyl)-N-methyl-4,4-diphenyl-2,3-butadienamid 
• 110700-12-4 N-(2,6-Dimethylphenyl)-N-methyl-2-(triphenylphosphoranyliden)acetamid 

Relevant academic research and scientific papers

Preparation method of 2, 6-dimethylaniline long-chain compound

The invention discloses a preparation method of a 2, 6-dimethylaniline long-chain compound. The method comprises S1, mixing a compound II and a compound III with a first solvent, and adding in a firstbase catalyst for reaction at 0-80 DEG C to obtain a compound IV; S2, uniformly mixing the compound IV prepared in S1, a compound V and a second solvent for mixed reaction at 70-120 DEG C, washing reaction products through ethyl acetate, and filtering out precipitates, namely a compound VI; S3, mixing the compound VI prepared in S2, a second base catalyst, a reactant A, alcohols and a third solvent for mixed reaction at 30-80 DEG C to obtain a compound I, wherein the reactant A is an acyl chloride or ester compound. According to the preparation method of the 2, 6-dimethylaniline long-chain compound, the applied raw materials are all common chemical materials and accordingly are wide in resource and low in prices, products of every reaction save complicated column chromatography and can berecrystallized into high-purity products, so that the preparation method of the 2, 6-dimethylaniline long-chain compound has an industrial scaled synthesis prospect.

Cycloadditions, 16. - Influence of Alkyl and Phenyl Groups in the Allenic ω-Position on the Intramolecular Diels-Alder Reactions of Allene Carbamides

The influences of methyl (partly of other alkyl) and phenyl moieties in the allenic ω-position on the isomerization tendencies of the N-phenyl- and N-(α-naphthyl)allenecarboxamides (5, 6 and 7, 8, resp.) are investigated.Methyl groups always decelerate (5, 7, 8 -> 9, 10, 11a-c), phenyl groups hinder (5f -> 9f and 12f), prevent (5, 6g), or accelerate (7f,g, 8g -> 10f,g, 11g) the intramolecular Diels-Alder reactions.The diphenyl compounds 5g, 6g cyclize to give the quinolones 12, 13; if this cyclization is prevented by two methyl groups in the ortho positions (s. 15), the common dimerization of allenes takes place to give the cyclobutane derivative 17. - Key Words: Allenecarboxamides/ Diels-Alder reaction/ Dimerization

Cycloadditions, 12. - Influence of Aromatic Alkyl Groups on the Intramolecular Diels-Alder Reaction of Aryl Allenecarboxylates and of Allenecarboxanilides

The aryl allenecarboxylates 4a-o and the allenecarboxanilides 9a, b, e, h, and l, which differ from one another only by the number or by the size of the alkyl groups attached to the arene, are synthesized by the ylide method via the appropriately substituted 2-halo-, 2-phosphonio-, and 2-phosphoranylideneacetic acid derivatives (1-->2-->3-->4 and 6-->7-->8-->9, resp.).By refluxing in xylene they are transformed into the tricyclic compounds 5 and 10; the rates and their differences are discussed.

Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry

Novel compounds of the general formula STR1 and the pharmaceutically acceptable esters and acid addition salts thereof, wherein: R1, R2, R3, R4 and R5 are each independently hydrogen, lower alkyl, lower alkoxy, cyano, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, N-optionally substituted alkylamido, except that when R1 is methyl, R4 is not methyl; or R2 and R3 together form --OCH2 O--; R6, R7, R8, R9 and R10 are each independently hydrogen, lower acyl, aminocarbonylmethyl, cyano, lower alkyl, lower alkoxy, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, di-lower alkyl amino; or R6 and R7 together form --CH=CH--CH=CH--; R7 and R8 together form --OCH2 O--; R11 and R12 are each independently hydrogen or lower alkyl; and W is oxygen or sulfur. These cardioselective compounds have calcium entry blockade properties and therefore are useful in therapy in the treatment of cardiovascular diseases, including arrhythmias, variant and exercise induced angina and myocardial infarction.

BENZODIOXANYL-HYDROXYETHYLENEAMINO-PIPERIDINYL ACETANILIDES, KETONES, ESTERS AND CARBAMATES WHICH EFFECT IMMUNITY AND CALCIUM ENTRY AND BETA-BLOCKADE

Novel compounds of the general formula: STR1 and the pharmaceutically acceptable acid addition salts thereof, wherein: R 1, R 2, R 3 and R 4 are each independently hydrogen, lower alkyl, lower alkoxy, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl or lower alkyl sulfonyl;R 5 is hydrogen or lower alkyl;m is 0 or 1;W is alkylene,--CH=CH--,--O--, or--N(R 6)--, where R 6 is lower alkyl or hydrogen;n is 0 or 1; andQ is lower alkyl, cycloalkyl or optionally substituted phenyl. These compounds combine β-blockade and calcium entry blockade properties in the same compound and therefore are useful in therapy in the treatment of cardiovascular diseases, including myocardial infarction, hypertension, arrhythmia and variant and exercise induced angina. The compounds are also useful in immunosuppressant therapy for immune diseases, such as rheumatoid arthritis.

Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade

Novel compounds of the general formula: STR1 and the pharmaceutically acceptable esters and acid addition salts thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each independently hydrogen, lower alkyl, lower alkoxy, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl; or R2 and R3 together form --OCH2 O--; and R10 and R11 are each independently hydrogen or lower alkyl. These compounds combine β-blockade and calcium entry blockade properties in the same compound and therefore are useful in therapy in the treatment of cardiovascular diseases, including hypertension, arrhythmias and variant and exercise induced angina.

Process for the production of tertiary 2-haloacetamides

The disclosure herein relates to a novel process for producing tertiary 2-haloacetamides by reacting primary or secondary 2-haloacetamides with an agent capable of generating an anion of the primary or secondary 2-haloacetamide under base conditions and a