83020-58-0Relevant academic research and scientific papers
Direct C(sp2)-C(sp3) cross-coupling of diaryl zinc reagents with benzylic, primary, secondary, and tertiary alkyl halides
Dunsford, Jay J.,Clark, Ewan R.,Ingleson, Michael J.
, p. 5688 - 5692 (2015)
The direct C(sp2)-C(sp3) cross-coupling of diaryl zinc reagents with benzylic, primary, secondary, and tertiary alkyl halides proceeded in the absence of coordinating ethereal solvents at ambient temperature without the addition of a catalyst. The C(sp2)-C(sp3) cross-coupling showed excellent functional-group tolerance, and products were isolated in high yields, generally without the requirement for purification by chromatography. This process represents an expedient, operationally simple method for the construction of new C(sp2)-C(sp3) bonds. Zinc and you'll miss it. Direct C(sp2)-C(sp3) cross-coupling of diaryl zinc reagents with alkyl halides proceeded rapidly at ambient temperature without a coordinating ethereal solvent or an added catalyst (see scheme). This versatile, operationally simple approach to C(sp2)-C(sp3) bond formation enables the expedient construction of a diverse array of carbon-based structural motifs.
Definitive evidence for inhibition of calix[6]arene ring inversion obtained from a 1,3-xylenyl-bridged chiral calix[6]arene
Otsuka, Hideyuki,Shinkai, Seiji
, p. 4271 - 4275 (1996)
To design calix[6]arene-based receptor molecules which show high affinity and high selectivity toward guest molecules, the construction of more rigid and conformationally-defined analogs has been long awaited (Gutsche; Alam Tetrahedron 1988, 44, 4689). It
