83021-72-1Relevant academic research and scientific papers
The Structure-Reactivity-Chemoselectivity Relationship on the Reactions of 1-Unsubstituted Tautomeric 2-Pyridones with Benzyne
Kuzuya, Masayuki,Noguchi, Akihiro,Mano, Ei-ichi,Okuda, Takachiyo
, p. 1149 - 1155 (2007/10/02)
The reactions of 2-pyridones with benzyne were investigated in order to gain some insight into the structure-reactivity-chemoselectivity relatinoship involved in the tautomeric systems.All reactions examined have resulted in the formation of Diels-Alder and Michael-type adducts.It has been shown that the Diels-Alder reactivities were well correlated with the HOMO energy levels of the 2-pyridone form and the yields of the Michael-type adduct were closely associated with the tautomeric equilibria.In summary, the chemoselectivities of 2-pyridones in the reaction with benzyne were largely affected by the tautomeric properties.
DEILS-ALDER ADDUCTS FROM N-SUBSTTITUED TAUTOMERIC 2(1H)-PYRIDONE-2-HYDROXYPYRIDINES; 5,6-BENZO-AZABARRELENONES AND 5,6-BENZO-AZABARRELENES
Kuzuya, Masayuki,Mano, Ei-ichi,Adachi, Michihiro,Noguchi, Akihiro,Okuda, Takachiyo
, p. 475 - 478 (2007/10/02)
Diels-Alder reactions of several N-unsubstitued tautomeric 2(1H)-pyridone-2-hydroxypyridines with benzyne were examined and found to afford 5,6-azabarrelenones, wich were converted to hitherto unknown 5,6-benzo-azabarrelenes.
