83022-58-6

Usage

Type of compound

Ketone

Structure

Contains a propan-1-one group attached to a phenyl ring

Substitution

Phenyl ring substituted with a difluoromethoxy group at the 4-position

Industry use

Pharmaceutical and chemical industries

Application

Building block for the synthesis of various organic compounds

Potential applications

Medicinal chemistry and drug discovery

Unique properties

Stability and lipophilicity due to the difluoromethoxy group

Suitability

Incorporation into drug candidates or agrochemicals

Research status

Specific biological and chemical properties not extensively studied

Further research

Needed to fully understand potential applications and effects

Upstream product

• 75-45-6 Chlorodifluoromethane 
• 70-70-2 4-hydroxypropiophenone 

Downstream Products

• 130339-51-4 dl-α-ethyl-4-difluoromethoxybenzylamine 
• 452930-62-0 4-difluoromethoxypropiophenone oxime 

Relevant academic research and scientific papers

Synthesis of benzylaminopyrimidines and their fungicidal activities against wheat brown rust and barley powdery mildew

Members of a new class of fungicide containing benzyl-aminopyrimidine as a core structure were synthesized and their fungicidal potencies against wheat brown rust, Puccinia recondita, and barley powdery mildew, Erysiphe graminis, were assessed. Among these fungicides, N-(fluoroalkoxy or fluorophenoxybenzyl)-4-pyrimidinamines showed notable preventive activities. The potency of the new pyrimidines was increased when a difluoromethoxy or tetrafluorophenoxy group was introduced at the 4- or 3-position of the phenyl moiety and a methyl or ethyl group was introduced at the benzyl position. Structure-activity relationships are discussed.

Phenyl ketone derivatives

Ketone derivatives represented by the general formula (I) STR1 where R is --CH2 R1 (where R1 is a hydrogen atom or an alkyl group), a halogen-substituted alkyl group, a cyano-substituted alkyl group, a cyclopropyl group, STR2 (where R2 is a hydrogen atom or an alkyl group and Y is a hydrogen atom or a halogen atom) or STR3 (where R3 is a hydrogen atom, an alkyl group, a phenyl group or a halogen-substituted phenyl group, and Z is a hydrogen atom or a halogen atom), and X is an oxygen atom or a sulfur atom.