83023-56-7

Usage

Uses

Used in Pharmaceutical Industry:
(2R)-5-BROMO-3-(2-PYRROLIDINYL)PYRIDINE is used as a chemical intermediate for the development of new drugs, leveraging its potential biological activity to create therapeutic agents that address various health conditions. Its unique structure, including the bromine atom and pyrrolidine ring, may contribute to its efficacy and selectivity in medicinal applications.

Upstream product

• 113118-81-3 5-bromopyridine-3-carbaldehyde 
• 71719-06-7 5-Bromo-3-(2-pyrrolidinyl)pyridine 
• 263888-13-7 (2'R)-N'-[(1R,2S,5R)-Menthoxycarbonyl]-5-bromonornicotine 
• 64319-85-3 3-bromo-5-(4,5-dihydro-3H-pyrrol-2-yl)-pyridine 
• 20986-40-7 ethyl 5-bromo-3-pyridinecarboxylate 

Downstream Products

• 350820-87-0 (2R)-2-(3-pyridinyl)-1-pyrrolidinebutanoic acid phenylmethyl ester 
• 7076-23-5 (+)-nornicotine 

Relevant academic research and scientific papers

Enantioselective Synthesis of Nicotine via an Iodine-Mediated Hofmann-L?ffler Reaction

An iodine-mediated Hofmann-L?ffler reaction has been developed that enables the first enantioselective synthesis of nicotine based on this synthetic methodology. The effect of the free pyridine core on the involved electrophilic iodine reagents was explored in detail. The final synthesis proceeds under moderate reaction conditions that tolerate the free pyridine core. The same synthetic sequence is also applicable to a number of derivatives with higher substituted pyridine cores, including bipyridine derivatives.

Metabolism of N'-nitrosonornicotine enantiomers by cultured rat esophagus and in vivo in rats

People who use tobacco products are exposed to considerable amounts of N'-nitrosonornicotine (NNN), a well-established esophageal carcinogen in rats. NNN is believed to play a significant role as a cause of esophageal and oral cavity cancer in smokers and