83031-02-1

Upstream product

• 586-95-8 pyridine-4-methanol 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 1822-51-1 4-picolylchloride hydrochloride 

Downstream Products

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 83031-01-0 Boc-Pro-Pro-Gly-Phe-Ser(Bzl)-Pro-Phe-OPic 
• 83030-90-4 (S)-2-[((S)-1-{(S)-3-Benzyloxy-2-[(S)-3-phenyl-2-(2-{[(S)-1-((S)-pyrrolidine-2-carbonyl)-pyrrolidine-2-carbonyl]-amino}-acetylamino)-propionylamino]-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-phenyl-propionic acid pyridin-4-ylmethyl ester 
• 83031-00-9 Boc-Pro-Gly-Phe-Ser(Bzl)-Pro-Phe-OPic 
• 83030-99-3 Boc-Gly-Phe-Ser(Bzl)-Pro-Phe-OPic 
• 83030-98-2 Boc-Phe-Ser(Bzl)-Pro-Phe-OPic 
• 83030-97-1 Boc-Ser(Bzl)-Pro-Phe-OPic 
• 24050-88-2 Boc-Pro-Phe-OPic 
• 47507-91-5 (S)-3-Phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionic acid pyridin-4-ylmethyl ester 
• 83030-91-5 N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine 4-picolyl ester 
• 83030-58-4 Boc-Arg(NO₂)-Pro-Pro-Gly-Phe-Ser(Bzl)-Pro-Phe-OPic 
• 83030-59-5 N^α-t-butoxycarbonyl-N^ω-nitro-L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanylhydrazide 
• 83030-92-6 N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine 
• 83030-60-8 N^α-t-butoxycarbonyl-N^ω-nitro-L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine 

Relevant academic research and scientific papers

Carbon dots as photocatalysts for organic synthesis: Metal-free methylene-oxygen-bond photocleavage

We report for the first time that irradiation of four different citric acid-derived carbon dots (CDs), in the absence of any other redox mediators, promotes an organic reaction. In this proof-of-concept study methylene-oxygen bond reductive photocleavage in N-methyl-4-picolinium esters is demonstrated. Cyclic voltammetry and UV-Vis spectra of the CDs and of the esters indicate that photocleavage reactivity correlates with the redox properties and the relative energies expressed in the Fermi scale. A photo-fragmentation mechanism is proposed. This study offers a new possibility to employ inexpensive and readily available CDs to promote photo-organic reactions.

Visible Light Photorelease of Carboxylic Acids via Charge-Transfer Excitation of N-Methylpyridinium Iodide Esters

Iodide contrast sensitization to direct irradiation of charge transfer salts incurs carboxylic acid release via visible light absorption. The photochemical reduction of N-methyl-4-pyridinium iodide esters to release carboxylic acids is examined using 1H NMR analysis. Photolysis reactions are carried out under mild, biphasic solvent conditions using a household LED lamp. Carboxylic acid release is reported in high yields, and the viability of this method for synthetic chemistry is demonstrated through a macroscale reaction.

A mild method for the cleavage of the 4-picolyloxy group with magnesium under neutral conditions

A mild and efficient method for the selective hydrolysis of 4-picolyl esters with magnesium in methanol or water in the presence of other esters and sensitive protecting groups is described. 4-Picolyl aryl ethers and thioethers are also smoothly deprotected to give the corresponding phenols and thiophenols. Georg Thieme Verlag Stuttgart. New York.

Amino-acids and Peptides. Part 46. Synthesis of Bradykinin Analogues Modified in the Vicinity of the Carboxy-group

In order to investigate further the effect on biological activity of structural changes in the vicinity of the terminal carboxy-group, the following analogues of bradykinin have been synthesised by the picolyl ester method: bradykinyl-L-isoleucine (2), -L