83060-72-4

Basic information

• Product Name: 3-AMINO-2-CYANO-5-PHENYLTHIOPHENE
• Synonyms: 3-AMINO-2-CYANO-5-PHENYLTHIOPHENE;3-Amino-5-phenyl-thiophene-2-carbonitrile;3-amino-5-phenyl-2-Thiophenecarbonitrile
• CAS NO: 83060-72-4
• Molecular Formula: C₁₁H₈N₂S
• Molecular Weight: 200.26
• Mol File: 83060-72-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 437.898°C at 760 mmHg
• Flash Point: 218.633°C
• Appearance: /
• Density: 1.303g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.676
• CAS DataBase Reference: 3-AMINO-2-CYANO-5-PHENYLTHIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-2-CYANO-5-PHENYLTHIOPHENE(83060-72-4)
• EPA Substance Registry System: 3-AMINO-2-CYANO-5-PHENYLTHIOPHENE(83060-72-4)

Safety Data

• Hazardous Substances Data: 83060-72-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 23, p. 1757, 1986 DOI: 10.1002/jhet.5570230631

InChI:InChI=1/C11H8N2S/c12-7-11-9(13)6-10(14-11)8-4-2-1-3-5-8/h1-6H,13H2

Upstream product

• 62-53-3 aniline 
• 107-14-2 chloroacetonitrile 
• 78583-84-3 3-chloro-3-phenylprop-2-enenitrile 
• 83060-70-2 3-amino-5-phenylthiophene-2-thiocarboxamide 
• 935-02-4 3-Phenyl-2-propynonitrile 
• 54524-32-2 mercaptoacetonitrile sodium salt 

Downstream Products

• 109879-84-7 2,6-diphenyl-4-(methylthio)thieno<3,2-d>pyrimidine 
• 109879-80-3 2,6-diphenyl-4-thio-3H-thieno<3,2-d>pyrimidine 
• 109879-86-9 4-amino-2,6-diphenylthieno<3,2-d>pyrimidine 
• 109879-85-8 2,6-diphenyl-4-chlorothieno<3,2-d>pyrimidine 
• 109879-82-5 2-methyl-4-(methylthio)-6-phenylthieno<3,2-d>pyrimidine 
• 109879-78-9 2-methyl-6-phenyl-4-thio-3H-thieno<3,2-d>pyrimidine 
• 109879-70-1 4-amino-2-methyl-6-phenylthieno<3,2-d>pyrimidine 
• 109879-76-7 3-dibenzoylamino-5-phenylthiophene-2-carbonitrile 
• 109879-69-8 3-methoxyacetimino-5-phenylthiophene-2-carbonitrile 
• 109879-74-5 3-(acetylamino)-5-phenylthiophene-2-carbonitrile 
• 122375-70-6 3-amino-5-phenylthiophene-2-carboxamide 
• 83060-70-2 3-amino-5-phenylthiophene-2-thiocarboxamide 
• 109879-88-1 2,4-diamino-6-phenylthieno<3,2-d>pyrimidine 

Relevant articles and documents

2-Bromo-2-chloro-3-arylpropanenitriles as C-3 Synthons for the Synthesis of Functionalized 3-Aminothiophenes

2-Bromo-2-chloro-3-arylpropanenitriles can be prepared by Meerwein reaction from 2-chloroacrylonitrile and various aryldiazonium salts under copper(II) bromide catalysis. They proved to be stable compounds which form 2-chlorocinnnamonitriles upon treatment with bases. Reaction of the title compounds with substituted thioglycolates gave substituted 3-aminothiophenes which have not yet been accessible by other routes. Three-component reactions with the title compound, sodium sulfide and bromonitromethane, chloroacetonitrile, or ethyl 4-chloroacetoacetate gave 2-nitro- and 2-cyano-substituted 3-aminothiophenes, and thienopyridinediones in high yields and in one single step, respectively.

ANTI-CANCER DRUGS AND USES RELATING THERETO FOR METASTATIC MALIGNANT MELANOMA AND OTHER CANCERS

The present invention discloses triazene analogs of the general formula (I) and formula (II), their tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, and pharmaceutically acceptable salts thereof for the metastatic malignant melanoma and other cancers including but not limited to lymphomas, sarcomas, carcinomas, and gliomas. The invention further discloses a process for the preparation of the above said triazene analogs of formula (I) and formula (II), and their pharmaceutically acceptable compositions.

Facile Conversion on Primary Thioamides into Nitriles with Butyltin Oxides

-