83067-95-2

Upstream product

• 83067-94-1 4-oxo-1,4-dihydro-[1,5]naphthyridin-3-yl carboxylic acid ethyl ester 
• 13801-51-9 4-hydroxy-1,5-naphthyridine-3-carboxylic acid ethyl ester 
• 14029-71-1 2-(pyridin-3-yl)aminomethylene-malonic acid diethyl ester 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 462-08-8 pyridin-3-ylamine 

Downstream Products

• 83067-98-5 3-Ethoxycarbonyl-4-phenylamino-1,5-napthyridine 
• 83068-03-5 3-Ethoxycarbonyl-4-benzylthio-1,5-naphthyridine 
• 83068-01-3 3-Carboxy-4-anilino-1,5-naphthyridine 
• 83068-00-2 3-Carboxy-4-amino-1,5-naphthyridine 
• 83068-06-8 1-Phenyl-3-hydroxypyrazolo<4,3-c>-1,5-naphthyridine 
• 83068-07-9 1H-2-Phenyl-3-oxo-2,3-dihydropyrazolo<4,3-c>-1,5-naphthyridine 

Relevant academic research and scientific papers

Pharmaceutical composition for promoting fracture healing, preparation method thereof and application thereof

The invention relates to the technical field of medicines and discloses a pharmaceutical composition for promoting the fracture healing. Structurally speaking, the active ingredient of the pharmaceutical composition has the following structure: (img file = 'DDA0001638481410000011. TIF' wi= '347' he= '319'/) The pharmaceutical composition is mainly used for preparing medicines for promoting fracture healing. As far as action is concern, that medicine has good therapeutic effect on osteoporotic fracture, obviously promotes fracture heal, reduces blood viscosity, and has important promoting effect on osteocyte growth.

MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.