83073-99-8Relevant articles and documents
Novel dithiocarbamate carbapenems with anti-MRSA activity
Ohtake, Norikazu,Imamura, Hideaki,Jona, Hideki,Kiyonaga, Hideo,Shimizu, Aya,Moriya, Minoru,Sato, Hiroki,Nakano, Masato,Ushijima, Ryosuke,Nakagawa, Susumu
, p. 1089 - 1101 (1998)
A new series of 1β-methyl carbapenems, in which a disubstituted-aminothiocarbonylthio moiety was attached to the C-2 position of the carbapenem nucleus, were prepared and evaluated for anti-MRSA activity. These derivatives showed good in vitro antibacterial activity against high-level MRSA, and the finding of good affinity for PBP-2' supported these results. Some of the compounds having favorable protein-binding affinity showed excellent in vivo anti-MRSA activity. Copyright (C) 1998 Elsevier Science Ltd.