83086-55-9Relevant academic research and scientific papers
Scaling-out pharmaceutical reactions in an automated stop-flow microwave reactor
Moseley, Jonathan D.,Woodman, Emily K.
, p. 967 - 981 (2008)
Six pharmaceutically relevant reactions were assessed for scaleout in an automated stop-flow microwave reactor. Daily throughputs of between 50 and 250 g were achieved at typical reaction concentrations; for more concentrated reactions, or with 24 h proce
A comparison of commercial microwave reactors for scale-up within process chemistry
Moseley, Jonathan D.,Lenden, Philip,Lockwood, Mark,Ruda, Katinka,Sherlock, Jon-Paul,Thomson, Anthony D.,Gilday, John P.
supporting information, p. 30 - 40 (2012/12/31)
Seven commercially available microwave reactors designed for limited scale-up have been investigated using a highly reliable and robust reaction (the Newman-Kwart rearrangement). The use of a single reaction has enabled the comparison to be made across the range of different reactor types and scales. Overall, all reactors gave reliable scale-up from small scale, and performance equivalent to one another on large scale. A more detailed comparison between them is given in the concluding section.
(2-Aryl-4-phenylthioalkyl-1,3-dioxolan-2-ylmethyl)azole derivatives
-
, (2008/06/13)
The present invention relates to a series of (2-aryl-4-phenylthioalkyl-1,3-dioxolan-2-ylmethyl)azole derivatives which are useful as antifungal and antineoplastic agents.
