53827-87-5

Upstream product

• 67-56-1 methanol 
• 85344-81-6 O,O-dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate 
• 2581-34-2 3-methyl-4-nitrophenol 
• 83086-55-9 3-methyl-4-nitrophenyl-S-thiocarbamate 
• 83086-54-8 O-(3-methyl-4-nitrophenyl)dimethylcarbamothioate 
• 5367-28-2 5-chloro-2-nitrotoluene 
• 446-33-3 5-Fluoro-2-nitrotoluene 
• 122-14-5 MEP 
• 1455-13-6 deuteromethanol 

Downstream Products

• 308814-40-6 2-methyl-4-(methylthio)-1-nitrobenzene 
• 1321821-88-8 3,5-dimethyl-1-[(3-methyl-4-nitrophenyl)sulfonyl]piperidine 
• 53827-86-4 3-Methyl-4-nitrophenyl-2-nitrophenylsulfid 
• 53827-47-7 (3-Methyl-4-nitro-phenylsulfanyl)-acetic acid methyl ester 

Relevant academic research and scientific papers

USE OF COMPOUND BINDING TO MSIN3B THAT SPECIFICALLY BINDS TO NEURON RESTRICTIVE SILENCER FACTOR (NRSF)

The present invention identifies a compound which binds to the PAH1 domain of mSin3B that specifically binds to neural restrictive silencer factor NRSF, and uses the compound as a prophylactic and/or a therapeutic for diseases associated with abnormal exp

Scaling-out pharmaceutical reactions in an automated stop-flow microwave reactor

Six pharmaceutically relevant reactions were assessed for scaleout in an automated stop-flow microwave reactor. Daily throughputs of between 50 and 250 g were achieved at typical reaction concentrations; for more concentrated reactions, or with 24 h proce

A comparison of commercial microwave reactors for scale-up within process chemistry

Seven commercially available microwave reactors designed for limited scale-up have been investigated using a highly reliable and robust reaction (the Newman-Kwart rearrangement). The use of a single reaction has enabled the comparison to be made across the range of different reactor types and scales. Overall, all reactors gave reliable scale-up from small scale, and performance equivalent to one another on large scale. A more detailed comparison between them is given in the concluding section.

Non-nucleoside reverse transcriptase inhibitors

The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R1-R5, R7a, R7b, R7c, R8-R10, X1, X2 m, n, o and p are as defined herein.

Solvent deuterium kinetic isotope effects for the methanolyses of neutral C=O, P=O and P=S esters catalyzed by a triazacyclododecane : Zn 2+-methoxide complex

The methanolyses of several organophosphate/phosphonate/phosphorothioate esters (O, O-diethyl O-(4-nitrophenyl) phosphate, paraoxon, 3; O, O-diethyl S-(3,5-dichlorophenyl) phosphorothioate, 4; O-ethyl O-(2-nitro-4-chlorophenyl) methylphosphonate, 5; O, O-dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate, fenitrothion, 6; O-ethyl S-(3,5-dichlorophenyl) methylphosphonothioate 7) and a carboxylate ester (p-nitrophenyl acetate, 2) catalyzed by methoxide and the Zn2+(-OCH3) complex of 1,5,9- triazacyclododecane (1 : Zn2+(-OCH3)) were studied in methanol and d1-methanol at 25°C. In the case of the methoxide reactions inverse skie's were observed for the series with values ranging from 2 to 1.1, except for 7 where the kD/kH = 0.90 ± 0.02. The inverse kD/kH values are consistent with a direct nucleophilic methoxide attack involving desolvation of the nucleophile with varying extents of resolvation of the TS. With the 1 : Zn 2+(-OCH3) complex all the skie values are kD/kH = 1.0 ± 0.1 except for 7 where the value is 0.79 ± 0.06. Arguments are presented that the fractionation factors associated with complex 1 : Zn2+(-OCH3) are indistinguishable from unity. The skie's for all the complex-catalyzed methanolyses are interpreted as being consistent with an intramolecular nucleophilic attack of the Zn2+-coordinated methoxide within a pre-equilibrium metal : substrate complex. The Royal Society of Chemistry 2005.

Method of decomposing organophosphorus compounds

Methods and kits for decomposing organophosphorus compounds in non-aqueous media at ambient conditions are described. Insecticides, pesticides, and chemical warfare agents can be quickly decomposed to non-toxic products. The method comprises combining the organophosphorus compound with a non-aqueous solution, preferably an alcohol, comprising metal ions and at least a trace amount of alkoxide ions. In a first preferred embodiment, the metal ion is a lanthanum ion. In a second preferred embodiment, the metal ion is a transition metal.