83104-85-2

Basic information

• Product Name: Glycine,N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-N-[2-[[8-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-,(acetyloxy)methyl ester
• Synonyms: Quin 2acetoxymethyl ester;Quin 2AM;(acetyloxy)methyl [{2-[(acetyloxy)methoxy]-2-oxoethyl}(2-{[8-(bis{2-[(acetyloxy)methoxy]-2-oxoethyl}amino)-6-methoxyquinolin-2-yl]methoxy}-4-methylphenyl)amino]acetate
• CAS NO: 83104-85-2
• Molecular Formula: C38H43N3O18
• Molecular Weight: 829.7573
• Product Categories: Quinoline
• Mol File: 83104-85-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 865.6 °C at 760 mmHg
• Flash Point: 477.3 °C
• Appearance: Yellow orange solid
• Density: 1.36 g/cm³
• Vapor Pressure: 2.25E-30mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: ?20°C
• Solubility: DMSO: soluble
• CAS DataBase Reference: Glycine,N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-N-[2-[[8-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-,(acetyloxy)methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine,N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-N-[2-[[8-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-,(acetyloxy)methyl ester(83104-85-2)
• EPA Substance Registry System: Glycine,N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-N-[2-[[8-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-,(acetyloxy)methyl ester(83104-85-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 1-8-10
• Hazardous Substances Data: 83104-85-2(Hazardous Substances Data)

Usage

Description

Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 . As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a Kd value of 115 nM. It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH. High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells. Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.

Uses

Different sources of media describe the Uses of 83104-85-2 differently. You can refer to the following data:
1. 2-[(2-Amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)
2. Fluorescent probe for measurement of calcium in biological systems and for selected divalent cations.
3. Quin 2-AM is a cell permeable fluorescent probe for Ca2+ that gives a large shift in the UV absorption spectrum and a 20-fold increase in fluorescence upon Ca2+ binding.

InChI:InChI=1/C38H43N3O18/c1-23-7-10-31(40(14-34(46)56-19-52-24(2)42)15-35(47)57-20-53-25(3)43)33(11-23)51-18-29-9-8-28-12-30(50-6)13-32(38(28)39-29)41(16-36(48)58-21-54-26(4)44)17-37(49)59-22-55-27(5)45/h7-13H,14-22H2,1-6H3