83108-31-0

Upstream product

• 1193-18-6 3-methylcyclohexen-2-one 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 143459-20-5 (+/-)-ethyl 2-[2-hydroxy-4-methylcyclohex-3-enyl]-acetate 
• 844695-89-2 ethyl (4,4-dimethyl-2-oxocyclohexyl)acetate 
• 1197850-40-0 ethyl 2-[(1RS,2S)-2-hydroxy-4-methylcyclohex-3-enyl]acetate 

Relevant academic research and scientific papers

Stereoselective Total Synthesis of (±)-Pleurospiroketals A and B

A full account of our efforts toward the stereoselective total synthesis of sesquiterpenoid-derived natural products (±)-pleurospiroketals A and B is described. Commercially available 3-methyl-2-cyclohexenone and 2,2-dimethyloxirane were used as key build

Construction of Morphan Derivatives by Nitroso–Ene Cyclization: Mechanistic Insight and Total Synthesis of (±)-Kopsone

A type II nitroso–ene cyclization was developed for the construction of morphan derivatives with good functional-group tolerance. DFT calculations revealed that the nitroso–ene reaction proceeds in a stepwise manner involving diradical or zwitterionic intermediates. The rate-determining step is C?N bond formation, followed by a rapid hydrogen-transfer step with a chair-conformation transition state. The current approach was also successfully applied in the first total synthesis of (±)-kopsone, a highly strained yet simple morphan-type alkaloid isolated from Kopsia macrophylla.

Total synthesis of racemic laurenditerpenol, an HIF-1 inhibitor

(Figure Presented) The convergent total synthesis of the HIF-1 inhibitor laurenditerpenol 1 and its diastereomer 1′ is reported. The key step involves the Julia-Kocienski olefination-reduction process between the sulfone 55 and the aldehyde 54. The unusual trimethylated oxanorbornane sulfone 55 was successfully synthesized from the known exo Diels-Alder adduct 24 of 2,5-dimethylfuran 7 and maleic anhydride 23 in 8 steps. The aldehyde 54 was prepared by ring-opening and elaboration of lactone 41. In addition, four analogues of 1 were also successfully synthesized for biological testing.

PROCESSES FOR PRODUCTION OF WINE LACTONE AND ITS INTERMEDIATES AND APPLICATION OF THE LACTONE

The present invention provides a method for producing wine lactone, a method for producing intermediates that are usable in production of wine lactone, and techniques for the application of wine lactone. The method for producing the wine lactone (Compound

TREATMENT FOR ALZHEIMER'S DISEASE AND RELATED CONDITIONS

Compounds of formula (I): are useful in the treatment of diseases associated with deposition of β-amyloid in the brain.

Smoking compositions containing a hexahydrobenzofuranone flavorant

This invention provides smoking compositions which contains a 6-substituted hexahydrobenzofuranone flavorant additive. Under cigarette smoking conditions the flavorant additive enhances the aroma and flavor of the cigarette smoke.

Regiospecific Alkylation of 3-Substituted-2-cyclohexen-1-ones. Synthesis and Conformational Analysis of 6-(Carbethoxymethyl)-3-substituted-2-cyclohexen-1-ones

The reaction of 3-substituted-2-cyclohexen-1-ones 1-5 with lithium diisopropylamide in tetrahydrofuran, followed by ethyl bromoacetate, generated 6-(carbethoxymethyl)-3-substituted-2-cyclohexen-1-ones 6-10 in a 55-88percent yield, regardless of the stoich