83117-41-3

Upstream product

• 65-85-0 benzoic acid 
• 57852-42-3 resiniferinol-9,13,14-ortho-phenylacetate 
• 200264-94-4 Acetic acid (1R,2R,4S,5R,6S,8S)-5-benzyloxy-8-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-11-methylene-10-oxo-12-oxa-tricyclo[6.3.1.0^1,6]dodec-4-yl ester 
• 200265-11-8 Acetic acid (1R,2R,4S,5R,6S,8S)-5-benzyloxy-8-(tert-butyl-dimethyl-silanyloxymethyl)-10-hydroxy-2-methyl-11-methylene-12-oxa-tricyclo[6.3.1.0^1,6]dodec-4-yl ester 
• 200265-14-1 C₂₈H₅₀O₇Si₂ 
• 200265-18-5 Benzoic acid (2S,3aR,6aS,7R,8S,10R,10aR,10bS)-8-acetyl-7,8,10a-trihydroxy-2,10-dimethyl-3-oxo-3a-trimethylsilanyloxy-1,2,3,3a,4,6a,7,8,9,10,10a,10b-dodecahydro-benzo[e]azulen-5-ylmethyl ester 
• 200265-02-7 Benzoic acid (2S,3aS,3bR,4R,5aS,8aR,8bS,11aR)-5a-acetyl-3b-hydroxy-2,4-dimethyl-1,7-dioxo-11a-trimethylsilanyloxy-1,2,3,3a,3b,4,5,5a,8a,8b,11,11a-dodecahydro-6,8-dioxa-indeno[5,4-e]azulen-10-ylmethyl ester 
• 200264-98-8 C₂₉H₄₈O₈Si₂ 
• 200265-05-0 C₃₁H₄₂O₆Si 
• 200265-12-9 C₄₀H₆₀O₅Si₂ 
• 200265-03-8 Benzoic acid (2S,3aR,6aS,7R,8S,10R,10aR,10bS)-8-acetyl-8,10a-dihydroxy-2,10-dimethyl-3-oxo-7-phenylacetoxy-3a-trimethylsilanyloxy-1,2,3,3a,4,6a,7,8,9,10,10a,10b-dodecahydro-benzo[e]azulen-5-ylmethyl ester 
• 200264-96-6 Acetic acid (1R,2R,4S,5R,6S,8S,10R,11S)-11-allyl-5-benzyloxy-8-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-10-phenylethynyl-10-trimethylsilanyloxy-12-oxa-tricyclo[6.3.1.0^1,6]dodec-4-yl ester 
• 200265-21-0 C₄₁H₅₄O₇Si₂ 
• 200264-88-6 C₄₃H₆₄O₅Si₂ 

Downstream Products

• 57852-42-3 resiniferinol-9,13,14-ortho-phenylacetate 
• 71407-32-4 C₃₉H₄₂O₁₀ 

Relevant academic research and scientific papers

Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The homovanillyl moiety

Starting from ROPA (2), analogues of RTX (1a) modified on the acyl side chain were prepared and evaluated for vanilloid activity in HEK-293 cells over-expressing the human recombinant TRPV1. The ROPA motif provided an enhancement of potency sufficient to