831232-62-3Relevant academic research and scientific papers
Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors
Blackburn, Christopher,Duffey, Matthew O.,Gould, Alexandra E.,Kulkarni, Bheemashankar,Liu, Jane X.,Menon, Saurabh,Nagayoshi, Masayuki,Vos, Tricia J.,Williams, Juliet
experimental part, p. 4795 - 4799 (2010/10/02)
A high throughput screen identified N-aroylpyrazoline 1 as a selective inhibitor of the V600E mutant of B-Raf kinase. Parallel synthesis of acyl, aroyl, and sulfonyl derivatives led to the identification of several potent inhibitors in both enzymatic and cellular (pERK) assays such as compound 42.
