951895-34-4Relevant academic research and scientific papers
Discovery and optimization of pyrazoline compounds as B-Raf inhibitors
Duffey, Matthew O.,Adams, Ruth,Blackburn, Christopher,Chau, Ryan W.,Chen, Susan,Galvin, Katherine M.,Garcia, Khristofer,Gould, Alexandra E.,Greenspan, Paul D.,Harrison, Sean,Huang, Shih-Chung,Kim, Mi-Sook,Kulkarni, Bheemashankar,Langston, Steven,Liu, Jane X.,Ma, Li-Ting,Menon, Saurabh,Nagayoshi, Masayuki,Rowland, R. Scott,Vos, Tricia J.,Xu, Tianlin,Yang, Johnny J.,Yu, Shaoxia,Zhang, Qin
scheme or table, p. 4800 - 4804 (2010/10/04)
The discovery of novel pyrazoline derivatives as B-Raf (V600E) inhibitors is described in this report. Chemical modification of the pyrazoline scaffold led to the development of SAR and identified potent and selective inhibitors of B-Raf (V600E). Determin
Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors
Blackburn, Christopher,Duffey, Matthew O.,Gould, Alexandra E.,Kulkarni, Bheemashankar,Liu, Jane X.,Menon, Saurabh,Nagayoshi, Masayuki,Vos, Tricia J.,Williams, Juliet
scheme or table, p. 4795 - 4799 (2010/10/02)
A high throughput screen identified N-aroylpyrazoline 1 as a selective inhibitor of the V600E mutant of B-Raf kinase. Parallel synthesis of acyl, aroyl, and sulfonyl derivatives led to the identification of several potent inhibitors in both enzymatic and cellular (pERK) assays such as compound 42.
Certain pyrazoline derivatives with kinase inhibitory activity
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Page/Page column 106-107, (2008/12/06)
The present invention provides certain pyrazoline compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of various diseases.
