831247-52-0

Basic information

• Product Name: 3-[2-(4-iodophenoxy)acetylamino]benzoic acid methyl ester
• Synonyms: 3-[2-(4-iodophenoxy)acetylamino]benzoic acid methyl ester
• CAS NO: 831247-52-0
• Molecular Weight: 411.196
• Mol File: 831247-52-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-[2-(4-iodophenoxy)acetylamino]benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(4-iodophenoxy)acetylamino]benzoic acid methyl ester(831247-52-0)
• EPA Substance Registry System: 3-[2-(4-iodophenoxy)acetylamino]benzoic acid methyl ester(831247-52-0)

Safety Data

• Hazardous Substances Data: 831247-52-0(Hazardous Substances Data)

Upstream product

• 90794-33-5 4-iodophenoxyacetic acid ethyl ester 
• 540-38-5 p-Iodophenol 
• 4518-10-9 Methyl 3-aminobenzoate 
• 1878-94-0 4-iodophenoxyacetic acid 

Relevant articles and documents

COMPOUNDS THAT INHIBIT HIF-1 ACTIVITY, THE METHOD FOR PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION CONTAINING THEM AS AN EFFECTIVE COMPONENT

Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient. The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity against HIF-1, a transcription factor which plays an important role in the growth and metastasis of cancer, but not to general cytotoxicity. Thus, the HIF-inhibitor and a pharmaceutically acceptable salt thereof can be used as a therapeutic for various cancers such as liver cancer; stomach cancer and breast cancer. Also, the compound having inhibition activity against HIF-1 is useful in the treatment of diabetic retinopathy and arthritis, which are aggravated by HIF-1-mediated VEGF expression.

(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors

Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1α protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.