83158-06-9

Basic information

• Product Name: 5-[(3-methoxy-4-phenylmethoxy-phenyl)methyl]pyrimidine-2,4-diamine
• Synonyms: 5-[(3-methoxy-4-phenylmethoxy-phenyl)methyl]pyrimidine-2,4-diamine;2,4-Diamino-5-[4-benzyloxy-3-methoxybenzyl]pyrimidine;5-[[3-Methoxy-4-(benzyloxy)phenyl]methyl]-2,4-pyrimidinediamine;5-[4-(Benzyloxy)-3-methoxybenzyl]pyrimidine-2,4-diamine;GH-101
• CAS NO: 83158-06-9
• Molecular Formula: C₁₉H₂₀N₄O₂
• Molecular Weight: 0
• Mol File: 83158-06-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 589.4°C at 760 mmHg
• Flash Point: 310.2°C
• Appearance: /
• Density: 1.252g/cm³
• Vapor Pressure: 7.21E-14mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 5-[(3-methoxy-4-phenylmethoxy-phenyl)methyl]pyrimidine-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(3-methoxy-4-phenylmethoxy-phenyl)methyl]pyrimidine-2,4-diamine(83158-06-9)
• EPA Substance Registry System: 5-[(3-methoxy-4-phenylmethoxy-phenyl)methyl]pyrimidine-2,4-diamine(83158-06-9)

Safety Data

• Hazardous Substances Data: 83158-06-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H20N4O2/c1-24-17-10-14(9-15-11-22-19(21)23-18(15)20)7-8-16(17)25-12-13-5-3-2-4-6-13/h2-8,10-11H,9,12H2,1H3,(H4,20,21,22,23)

Upstream product

• 50-01-1 guanidine hydrochloride 
• 111453-12-4 Anilinomethylidene-4-benzyloxy-3-methoxydihydrocinnamicnitrile 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 111453-11-3 (Z)-2-(4-Benzyloxy-3-methoxy-benzyl)-3-morpholin-4-yl-acrylonitrile 

Relevant articles and documents

Efficient radiosynthesis and preclinical evaluation of [18F]FOMPyD as a positron emission tomography tracer candidate for TrkB/C receptor imaging

Herein we report an efficient radiolabeling of a 18F-fluorinated derivative of dual inhibitor GW2580, with its subsequent evaluation as a positron emission tomography (PET) tracer candidate for imaging of two neuroreceptor targets implicated in the pathophysiology of neurodegeneration: tropomyosin receptor kinases (TrkB/C) and colony stimulating factor receptor (CSF-1R). [18F]FOMPyD was synthesized from a boronic acid pinacolate precursor via copper-mediated 18F-fluorination concerted with thermal deprotection of the four Boc groups on a diaminopyrimidine moiety in an 8.7±2.8% radiochemical yield, a radiochemical purity >99%, and an effective molar activity of 187±93 GBq/μmol. [18F]FOMPyD showed moderate brain permeability in wild-type rats (SUVmax = 0.75) and a slow washout rate. The brain uptake was partially reduced (ΔAUC40–90 = 11.6%) by administration of the nonradioactive FOMPyD (up to 30 μg/kg). In autoradiography, [18F]FOMPyD exhibits ubiquitous distribution in rat and human brain tissues with relatively high nonspecific binding revealed by self-blocking experiment. The binding was blocked by TrkB/C inhibitors, but not with a CSF-1R inhibitor, suggesting selective binding to the former receptor. Although an unfavorable pharmacokinetic profile will likely preclude application of [18F]FOMPyD as a PET tracer for brain imaging, the concomitant one-pot copper-mediated 18F-fluorination/Boc-deprotection is a practical technique for the automated radiosynthesis of acid-sensitive PET tracers.

Pharmaceutical compositions

The compounds of the general Formula I STR1 (wherein R1 and R2 may be the same or different and each stands for hydrogen, hydroxy, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkoxy, C2-6 alkenyloxy or p