83164-90-3

Basic information

• Product Name: 2-chloro-N-(2,4-difluorophenyl)pyridine-3-carboxamide
• Synonyms: 2-Chloro-N-(2,4-difluorophenyl)nicotinamide; 3-pyridinecarboxamide, 2-chloro-N-(2,4-difluorophenyl)-
• CAS NO: 83164-90-3
• Molecular Formula: C₁₂H₇ClF₂N₂O
• Molecular Weight: 268.6466
• EINECS: 617-447-8
• Mol File: 83164-90-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 294.7°C at 760 mmHg
• Flash Point: 132°C
• Density: 1.476g/cm³
• Vapor Pressure: 0.0016mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: 2-chloro-N-(2,4-difluorophenyl)pyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-(2,4-difluorophenyl)pyridine-3-carboxamide(83164-90-3)
• EPA Substance Registry System: 2-chloro-N-(2,4-difluorophenyl)pyridine-3-carboxamide(83164-90-3)

Safety Data

• Hazardous Substances Data: 83164-90-3(Hazardous Substances Data)

Upstream product

• 49609-84-9 2-Chloronicotinoyl chloride 
• 367-25-9 2,4-difluorophenylamine 

Relevant articles and documents

Synthesis method of diflufenican

The invention discloses a synthesis method of diflufenican. The method comprises: (1) carrying out a phosgenation reaction on 2-chloronicotinic acid and phosgene, which are used as raw materials, in the presence of an organic solvent under the action of a catalyst to prepare 2-chloronicotinoyl chloride; (2) carrying out an amination reaction on the 2-chloronicotinoyl chloride and 2,4-difluoroaniline to prepare 2-chloro-3-(2,4-difluorophenyl)pyridinecarboxamide; and (3) carrying out an etherification reaction on the 2-chloro-3-(2,4-difluorophenyl)pyridinecarboxamide and m-trifluoromethylphenolto prepare the diflufenican. The method has the advantages of simple process, easy control of operation process conditions, high purity and high yield of the product, and few three wastes.