83165-74-6

Basic information

• Product Name: diethyl [1-({N-[(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)carbonyl]alanyl}amino)ethyl]phosphonate
• CAS NO: 83165-74-6
• Molecular Formula: C₂₁H₃₁N₄O₆P
• Molecular Weight: 466.4678
• Mol File: 83165-74-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 702.8°C at 760 mmHg
• Flash Point: 378.9°C
• Density: 1.234g/cm³
• Vapor Pressure: 1.34E-19mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: diethyl [1-({N-[(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)carbonyl]alanyl}amino)ethyl]phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl [1-({N-[(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)carbonyl]alanyl}amino)ethyl]phosphonate(83165-74-6)
• EPA Substance Registry System: diethyl [1-({N-[(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)carbonyl]alanyl}amino)ethyl]phosphonate(83165-74-6)

Safety Data

• Hazardous Substances Data: 83165-74-6(Hazardous Substances Data)

Upstream product

• 289658-75-9 Diethyl-N-(benzyloxycarbonyl)-L-alanyl-(2-decarboxy-DL-alanin-2-yl)phosphonat 
• 54788-35-1 diethyl 1-aminoethylphosphonate 
• 389-08-2 nalidixic Acid 

Relevant articles and documents

STUDIES ON THE SYNTHESIS OF CHEMOTHERAPEUTICS. PART XI. SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF PHOSPHONOPEPTIDES

A variety of phosphonopeptides, shown in 2 as a general formula, containg natural and/or unnatural amino acids were synthesized, and their in vitro antibacterial activities were examined.N-Protected amino acids were condensed with 1-amino-ethylphosphonic acid or its ester followed by deprotection and hydrolysis to give the requisite phosphonopeptides.Several compounds showed higher levels of activity against certain members of Gram-negative bacteria than those of Alafosfalin (1) as the standard phosphonopeptide.A brief discussion on structure-activity relationships is also described.