54788-35-1

Usage

Uses

Used in Pharmaceutical Industry:
1-Aminoethylphosphonic acid diethyl is used as a reagent in the preparation of heterocyclic phosphopeptides, which are important for the development of new drugs and therapeutic agents. These phosphopeptides have potential applications in the treatment of various diseases, including cancer, neurological disorders, and inflammatory conditions.
Used in Enzyme Research:
1-Aminoethylphosphonic acid diethyl is used in the study of the activity of Candida antarctica lipase B (CALB), an enzyme with potential applications in various industries, such as food, pharmaceutical, and biofuel production. By understanding the effects of 1-Aminoethylphosphonic acid diethyl on CALB, researchers can gain insights into enzyme function and develop more efficient biocatalysts.
Used in Adhesive Industry:
1-Aminoethylphosphonic acid diethyl is used as a component in the preparation of self-adhesive labels. Its unique chemical properties allow it to improve the adhesion properties of the labels, making them more effective and durable. This application is particularly useful in industries that require high-quality labeling, such as packaging, logistics, and product identification.

Upstream product

• 53145-08-7 diethyl 1-(hydroxyimino)ethylphosphonate 
• 762-04-9 Diethyl phosphonate 
• 75-07-0 acetaldehyde 
• 74292-98-1 diethyl N-p-methoxybenzyloxycarbonyl-1-aminoethylphosphonate 
• 125183-85-9 diethyl 1-diphenylphosphinaminoethanephosphonate 
• 762-04-9 phosphonic acid diethyl ester 
• 75-05-8 acetonitrile 
• 66788-53-2 diethyl (1-(2,2,2-trifluoro-acetamido)ethyl)phosphonate 
• 60593-26-2 (1-nitroethyl)-phosphonic acid diethyl ester 
• 15336-73-9 diethyl 1-hydroxyethylphosphonate 
• 54788-34-0 Diethyl N-benzyloxycarbonyl-1-aminoethylphosphonate 
• 78-38-6 ethylphosphonic acid diethyl ester 
• 17986-29-7 diethyl 1-azido-1-ethylphosphonate 
• 125183-81-5 diethyl 1-diphenylphosphinamino-1-methylidenemethanephosphonate 

Downstream Products

• 146036-88-6 1-(Benzyloxycarbonyl-glycyl-glycyl-amino)ethylphosphonate de diethyle 
• 289658-75-9 Diethyl-N-(benzyloxycarbonyl)-L-alanyl-(2-decarboxy-DL-alanin-2-yl)phosphonat 
• 126306-89-6 ester ethylique de l'acide (N-benzyloxycarbonyl)-L-alanyl-L-(amino-1)-ethylphosphonnique 
• 196514-48-4 [1-((S)-2-Benzyloxycarbonylamino-4-methylsulfanyl-butyrylamino)-ethyl]-phosphonic acid diethyl ester 
• 113719-28-1 ester ethylique de l'acide (N-benzyloxycarbonyl)-L-alanyl-L-(amino-1)-ethylphosphonique 
• 289658-78-2 diethyl 1-(N-benzyloxycarbonyl-L-phenylalanyl)aminoethylphosphonate 
• 78835-67-3 {1-[2-Benzyloxycarbonylamino-3-(4-chloro-phenyl)-propionylamino]-ethyl}-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

The Facile Synthesis of O,O-Dialkyl 1-Aminoalkanephosphonates

O,O-Dialkyl 1-hydroxyiminoalkanephosphonates 1, may be conveniently reduced to O,O-dialkyl 1-aminoalkanephosphonates 2, at ambient temperature by application of lithium borohydride/trimethylsilyl chloride

Synthesis and antimicrobial activity of phosphonopeptide derivatives incorporating single and dual inhibitors

In diagnostic microbiology, culture media are widely used for detection of pathogenic bacteria. Such media employ various ingredients to optimize detection of specific pathogens such as chromogenic enzyme substrates and selective inhibitors to reduce the presence of commensal bacteria. Despite this, it is rarely possible to inhibit the growth of all commensal bacteria, and thus pathogens can be overgrown and remain undetected. One approach to attempt to remedy this is the use of “suicide substrates” that can target specific bacterial enzymes and selectively inhibit unwanted bacterial species. With the purpose of identifying novel selective inhibitors, six novel phosphonopeptide derivatives based on D/L-fosfalin and β-chloro-L-alanine were synthesized and tested on 19 different strains of clinically relevant bacteria. Several compounds show potential as useful selective agents that could be exploited in the recovery of several bacterial pathogens including Salmonella, Pseudomonas aeruginosa, and Listeria.

Intensified Continuous Flow Michaelis-Arbuzov Rearrangement toward Alkyl Phosphonates

Herein is described the development of an intensified continuous flow process for the preparation of a library of alkyl phosphonates through a Michaelis-Arbuzov rearrangement. A careful process optimization and thorough analysis of the competitive reactions led to a very attractive protocol with unprecedented productivities (up to 4.97 kg of material per day) and a low environmental footprint with the absence of solvent, additives, catalysts, and waste. In-line low-field 31P NMR monitoring was conveniently implemented for rapid optimization and process monitoring. Two key alkyl phosphonate intermediates were also assessed for the unprecedented diazene dicarboxylate-mediated electrophilic amination under continuous flow conditions toward the α-aminophosphonic acid derivatives of Pphenylalanine and Palanine, bioisosters of the natural amino acids phenylalanine and alanine, respectively.

Antimicrobial Compounds

An antimicrobial compound, as well as the salts, derivatives and analogues thereof, said compound being represented by the general formula (I): wherein R1 represents a peptide part P1 or a peptide part P2.

Microwave-assisted synthesis of 1-aminoalkyl phosphonates under solvent-free conditions

A simple, efficient and general method has been developed for the synthesis of 1-aminoalkyl phosphonates through a one-pot reaction of aldehydes with amines in the presence of acidic alumina under solvent-free conditions using microwave irradiation. It wa

Surface-mediated solid phase reactions: A simple and new method for the synthesis of α-aminophosphonates under solvent-free conditions

Alumina-supported ammonium formate was found to be an efficient reagent for the synthesis of 1-aminophosphonates from aldehydes and diethyl phosphite. This method is an easy, rapid and high-yielding reaction for the synthesis of 1-aminophosphonates.

1-Aminoalkanephosphonates. Part II. A facile conversion of 1-aminoalkanephosphonic acids into O,O-diethyl 1-aminoalkanephosphonates

1-(N-Trifluoroacetylamino)alkanephosphonate O,O-diethyl esters 2C, obtained from parent 1-aminoalkanephosphonic acids 1, have been selectively deprotected on the amino function affording O,O-diethyl 1-aminoalkanephosphonates 3. Protonation constants of all amino esters 3 synthesized have been determined by potentiometric titration.

The facile synthesis of 1-aminophosphonates from 1-nitrophosphonate precursors

1-Aminophosphonates may be generated in high yield and spectroscopic purity by the treatment of 1-nitrophosphonates with LiBH4/Me3SiCl in THF at room temperature.

A simple synthesis of 1-aminophosphonic acids from 1-hydroxyiminophosphonates with NaBH4 in the presence of transition metal compounds

A new procedure has been developed for the synthesis of 1-aminophosphonic acids. Diethyl phosphonates are converted to hydroxyiminophosphonates when treated with hydroxylamine hydrochloride. Reduction of hydroiminophosphonates with NaBH4 in MeOH in the presence of MoO3 or NiCl2 and hydrolysis of 1-aminophosphonates gave 1-aminophosphonic acids in good yields.