83167-10-6Relevant academic research and scientific papers
A simple synthesis of 4-aroyl-5-methyl-1H-imidazol-2(3H)-one derivatives (Enoxymone analogues) from aryl methyl ketones via enaminones
Bezensek, Jure,Groselj, Uros,Stare, Katarina,Svete, Jurij,Stanovnik, Branko
, p. 294 - 307 (2014/03/21)
Aryl methyl ketones 1a-e gave with N,N-dimethylacetamide dimethylacetal (DMADMA) (E)-1- aryl-3-(dimethylamino)-but-2-en-1-ones 2a-e. Substitution of the N,N-(dimethylamino) group in the reaction with ammonium acetate afforded the corresponding (Z)-3-amino-1-aryl-but-2-en-1- ones 3a-e. In the reaction of 3a-e with diethyl azodicarboxylate intermediates 4a-e were formed, which were, in most cases without isolation, cyclized into ethyl (5-aroyl-4-methyl-2-oxo-2,3- dihydro-1H-imidazol-1-yl)carbamates 5a-e. Hydrolysis of the ester group, followed by the decarboxylation and deamination of intermediates 6a-c,e produced 4-aroyl-5-methyl-1Himidazol- 2(3H)-ones 7a-c,e.
4-Aroylimidazol-2-ones and their use as pharmaceuticals
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, (2008/06/13)
Novel 4-aroylimidazol-2-ones of the following general structure which are useful as antihypertensives, cardiotonics, antithrombotics, bronchodilators and uterospasmolytics STR1 wherein Ar is 2-furyl, 2-thienyl or phenyl, the latter of which may optionally
4-Aroyl-1,3-dihydro-2H-imidazol-2-ones, a new class of cardiotonic agents
Schnettler,Dage,Grisar
, p. 1477 - 1481 (2007/10/02)
A series of 4-aroyl-1,3-dihydro-2H-imidazol-2-ones was synthesized and evaluated for pharmacological activity in the anesthetized dog. Most members of this series produced dose-related increases in cardiac contractile force as well as relatively minor inc
