83174-90-7

Basic information

• Product Name: 1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbaldehyde
• Synonyms: 1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbaldehyde
• CAS NO: 83174-90-7
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.15
• Mol File: 83174-90-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 274.1°Cat760mmHg
• Flash Point: 122.6°C
• Appearance: /
• Density: 1.408g/cm³
• Vapor Pressure: 0.00551mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: 1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbaldehyde(83174-90-7)
• EPA Substance Registry System: 1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbaldehyde(83174-90-7)

Safety Data

• Hazardous Substances Data: 83174-90-7(Hazardous Substances Data)

Usage

Structure

A heterocyclic compound containing a pyrimidine ring with two methyl groups (-CH3) at the 1st and 3rd positions, a formyl group (-CHO) at the 4th position, and two oxygen atoms (O) at the 2nd and 6th positions.

Functional Groups

Methyl groups, formyl group, and carbonyl groups.

Physical State

Likely a solid at room temperature, based on its molecular weight and structure.

Solubility

Soluble in organic solvents such as ethanol, methanol, and acetone, due to its nonpolar nature.

Reactivity

Can undergo various chemical reactions, such as condensation, substitution, and reduction, due to the presence of different functional groups.

Applications

Used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals.

Synthesis

Can be synthesized through various methods, such as condensation reactions involving pyrimidine derivatives and aldehydes or ketones.

Stability

Relatively stable under normal conditions, but sensitive to strong acids, bases, and reducing agents.

Hazards

Potential irritant and harmful if inhaled, ingested, or comes into contact with the skin. Proper handling and storage are necessary to minimize risks.

InChI:InChI=1/C7H8N2O3/c1-8-5(4-10)3-6(11)9(2)7(8)12/h3-4H,1-2H3

Upstream product

• 13509-52-9 1,3,6-trimethyluracil 
• 116705-39-6 6-(2-dimethylaminovinyl)-1,3-dimethyluracil 
• 21326-23-8 6-(dimethoxymethyl)uracil 
• 36327-91-0 orotoaldehyde 
• 626-48-2 6-Methyluracil 
• 134924-81-5 6-Dimethoxymethyl-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 83174-91-8 1,3-dimethylorotaldehyde diethyl acetal 

Downstream Products

• 874-14-6 1,3-dimethyluracil 
• 134924-78-0 6-[Hydroxy-(5-methyl-furan-2-yl)-methyl]-1,3-dimethyl-1H-pyrimidine-2,4-dione 

Relevant articles and documents

PYRIDO[3,4-D]PYRIMIDINYL ACETAMIDE DERIVATIVES AS TRPA1 MODULATORS

Provided are pyrido[3,4-d]pyrimidinyl acetamide derivatives as Transient Receptor Potential Ankyrin (TRPA) modulators. In particular, the compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by Transient Receptor Potential Ankyrin 1 (TRPAl). Also provided herein are processes for preparing the compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. Formula (I).

Reactions of Uracils, 16. - Substituted 6-Vinyl-2,4(1H,3H)-pyrimidinediones in Cycloaddition and Michael-Type Reactions: Pyridopyrimidines, Pyrrolopyridines, and Quinazolines

Electron-rich 6-vinyl- and 6-(azavinyl)pyrimidinediones, such as 6-amino>- (1) and 6--1,3-dimethyl-2,4(1H,3H)-pyrimidinediones (8), undergo cycloaddition reactions with electron deficient olefins to give pyridopyrimidines (3a-e) and quinazolines (9a-c), respectively, after elimination of dimethylamine from the 1:1 cycloadducts and oxidative aromatization.With dimethyl acetylenedicarboxylate, pyrrolopyridines 5, 11, and 15 were obtained due to an initial Michael addition and subsequent ring transformation reaction.Stable Michael adducts were also obtained from reactions of 1 with azodicarboxylates.The stable adducts 6a-c were thermally converted into 8-(dimethylamino)theophylline (7). - Key Words: Pyridopyrimidines/ Pyrrolopyridines/ Quinazolines/ 6-Vinyl-2,4(1H,3H)-pyrimidinediones/ Cycloaddition