83177-82-6

Upstream product

• 135574-69-5 Benzoic acid (R)-((S)-2-benzoyl-7-hydroxy-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-(3-hydroxy-4-methoxy-phenyl)-methyl ester 
• 135574-24-2 Benzoic acid (R)-((S)-2-benzoyl-7-benzyloxy-6-methoxy-1,2-dihydro-isoquinolin-1-yl)-(3-benzyloxy-4-methoxy-phenyl)-methyl ester 
• 135574-23-1 (1R,2S)-1,2-Bis-(3-benzyloxy-4-methoxy-phenyl)-2-(2,2-dimethoxy-ethylamino)-ethanol 
• 133343-26-7 (4R,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-[1,3,2]dioxathiolane 2,2-dioxide 
• 133343-22-3 (4R,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-[1,3,2]dioxathiolane 2-oxide 
• 133343-21-2 (2R,3R)-2,3-Bis-(3-benzyloxy-4-methoxy-phenyl)-oxirane 

Downstream Products

• 72258-92-5 (+/-)-N-Formyl-N-norreticuline 
• 83177-83-7 N-formyl-α-hydroxy-N-norreticuline 

Relevant academic research and scientific papers

Short-cut in the pomeranz-fritsch synthesis of 1-benzyl-isoquinolines; short and efficient syntheses of norrecticuline derivatives and of papaverine

A new methodology for the Pomeranz-Fritsch synthesis of 1-benzyl-1,2-dihydroisoquinolines avoiding pavine or isopavine troubles, has been developed. These intermediates could be reduced to their 1,2,3,4-tetrahydro congeners or aromatized to give isoquinolines, as it was demonstrated by the synthesis of some norrecticuline derivatives 4-7 and of papaverin 8.