83193-30-0Relevant academic research and scientific papers
Preparation of functionalized aryl magnesium reagents by the addition of magnesium aryl thiolates and amides to arynes
Lin, Wenwei,Sapountzis, Ioannis,Knochel, Paul
, p. 4258 - 4261 (2007/10/03)
(Chemical Equation Presented) Reactive arynes, which are readily generated by the reaction of ortho-iocloarylsulfonates with iPrMgCl, undergo the smooth addition of various magnesium nucleophiles like magnesium thiolates, selenides, and amides. In all cases the resulting functionalized aryl magnesium species can be trapped by an electrophile leading to highly functionalized aromatic compounds (see scheme).
A concise synthesis of ortho-substituted aryl-acrylamides - Potent activators of soluble guanylyl cyclase
Zhang, Henry Q.,Xia, Zhiren,Kolasa, Teodozyj,Dinges, Jurgen
, p. 8661 - 8663 (2007/10/03)
Horner-Emmons reaction of phosphonate amides with aldehydes leads to generation of o-substituted aryl-acrylamides. These compounds have been shown to be useful to quickly establish structure-activity relationships (SAR) for soluble guanylyl cyclase (sGC)
POTENTIAL ANTIDEPRESSANTS: 1-(2-(METHOXY- AND HYDROXY-PHENYLTHIO)PHENYL)-2-PROPYLAMINES
Urban, Jiri,Sedivy, Zdenek,Holubek, Jiri,Svatek, Emil,Ryska, Miroslav,et al.
, p. 1077 - 1098 (2007/10/02)
2-(Methoxyphenylthio)benzaldehydes Xa-Xd were reacted with nitroethane in boiling acetic acid to give the corresponding 1-aryl-2-nitropropenes XIIa-XIId: benzonitriles XIIIa and XIIIc and benzaldoximes XXIc and XXId were isolated as by-products.Chromatogr
